| http://purl.uniprot.org/citations/15258149 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15258149 | http://www.w3.org/2000/01/rdf-schema#comment | "A chronic state of immune hyperactivation is a feature of human immunodeficiency virus type-1 (HIV-1) infection. Studies on the molecular mechanisms by which HIV-1 can modulate the activation state of T cells indicate that both Nef and Tat can alter T cell activation. However, the vast majority of data has been obtained from experiments performed with vectors encoding a single virus protein. We demonstrate that infection of human CD4(+) T lymphocytes with fully infectious HIV-1 leads to a hyper-responsiveness of the interleukin-2 promoter. Hypersensitivity in HIV-1-infected T cells was observed upon stimulation with various agents that are engaging different signal transduction pathways. Experiments performed with recombinant heat stable antigen-encoding HIV-1 indicated that the virus-infected cells are the cells with an enhanced response. Both Nef and Tat are involved in this virus-mediated enhancing effect on interleukin-2 promoter activity. Interestingly, whereas Nef seems to be acting mainly through hyperactivation of nuclear factor of activated T cells (NFAT), Tat acts in an NFAT-independent manner. Mobility shift experiments demonstrated that the HIV-1-associated priming of human T cells for stimulation results in a greater induction of transcription factors recognized as essential players in T cell activation, i.e. NFAT, NF-kappaB, and AP-1. A hyper-responsive state was also established upon HIV-1 infection of a more natural cellular reservoir, i.e. primary CD4(+) T lymphocytes. Considering that the HIV-1 life cycle is tightly regulated by the T cell signaling machinery, the priming for activation of a major viral reservoir represents a means by which this retrovirus can create an ideal cellular microenvironment for its propagation and maintenance."xsd:string |
| http://purl.uniprot.org/citations/15258149 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m407477200"xsd:string |
| http://purl.uniprot.org/citations/15258149 | http://purl.uniprot.org/core/author | "Barbeau B."xsd:string |
| http://purl.uniprot.org/citations/15258149 | http://purl.uniprot.org/core/author | "Barat C."xsd:string |
| http://purl.uniprot.org/citations/15258149 | http://purl.uniprot.org/core/author | "Tremblay M.J."xsd:string |
| http://purl.uniprot.org/citations/15258149 | http://purl.uniprot.org/core/author | "Beausejour Y."xsd:string |
| http://purl.uniprot.org/citations/15258149 | http://purl.uniprot.org/core/author | "Fortin J.F."xsd:string |
| http://purl.uniprot.org/citations/15258149 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15258149 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/15258149 | http://purl.uniprot.org/core/pages | "39520-39531"xsd:string |
| http://purl.uniprot.org/citations/15258149 | http://purl.uniprot.org/core/title | "Hyper-responsiveness to stimulation of human immunodeficiency virus-infected CD4+ T cells requires Nef and Tat virus gene products and results from higher NFAT, NF-kappaB, and AP-1 induction."xsd:string |
| http://purl.uniprot.org/citations/15258149 | http://purl.uniprot.org/core/volume | "279"xsd:string |
| http://purl.uniprot.org/citations/15258149 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15258149 |
| http://purl.uniprot.org/citations/15258149 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15258149 |
| http://purl.uniprot.org/uniprot/#_P04601-mappedCitation-15258149 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15258149 |
| http://purl.uniprot.org/uniprot/#_P04608-mappedCitation-15258149 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15258149 |
| http://purl.uniprot.org/uniprot/P04601 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15258149 |
| http://purl.uniprot.org/uniprot/P04608 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15258149 |