http://purl.uniprot.org/citations/15258591 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/15258591 | http://www.w3.org/2000/01/rdf-schema#comment | "Repulsive guidance molecule (RGM) is an axon guidance protein that repels retinal axons upon activation of the neogenin receptor. To understand the functions of RGM-neogenin complexes in vivo, we used gene transfer technology to perturb their expression in the developing neural tube of chick embryos. Surprisingly, neogenin over-expression or RGM down-expression in the neural tube induces apoptosis. Neogenin pro-apoptotic activity in immortalized neuronal cells and in the neural tube is associated with the cleavage of its cytoplasmic domain by caspases. Thus neogenin is a dependence receptor inducing cell death in the absence of RGM, whereas the presence of RGM inhibits this effect."xsd:string |
http://purl.uniprot.org/citations/15258591 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncb1157"xsd:string |
http://purl.uniprot.org/citations/15258591 | http://purl.uniprot.org/core/author | "Matsunaga E."xsd:string |
http://purl.uniprot.org/citations/15258591 | http://purl.uniprot.org/core/author | "Strittmatter S.M."xsd:string |
http://purl.uniprot.org/citations/15258591 | http://purl.uniprot.org/core/author | "Mehlen P."xsd:string |
http://purl.uniprot.org/citations/15258591 | http://purl.uniprot.org/core/author | "Tauszig-Delamasure S."xsd:string |
http://purl.uniprot.org/citations/15258591 | http://purl.uniprot.org/core/author | "Mueller B.K."xsd:string |
http://purl.uniprot.org/citations/15258591 | http://purl.uniprot.org/core/author | "Chedotal A."xsd:string |
http://purl.uniprot.org/citations/15258591 | http://purl.uniprot.org/core/author | "Monnier P.P."xsd:string |
http://purl.uniprot.org/citations/15258591 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
http://purl.uniprot.org/citations/15258591 | http://purl.uniprot.org/core/name | "Nat Cell Biol"xsd:string |
http://purl.uniprot.org/citations/15258591 | http://purl.uniprot.org/core/pages | "749-755"xsd:string |
http://purl.uniprot.org/citations/15258591 | http://purl.uniprot.org/core/title | "RGM and its receptor neogenin regulate neuronal survival."xsd:string |
http://purl.uniprot.org/citations/15258591 | http://purl.uniprot.org/core/volume | "6"xsd:string |
http://purl.uniprot.org/citations/15258591 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15258591 |
http://purl.uniprot.org/citations/15258591 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15258591 |
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