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http://purl.uniprot.org/citations/15258591http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/15258591http://www.w3.org/2000/01/rdf-schema#comment"Repulsive guidance molecule (RGM) is an axon guidance protein that repels retinal axons upon activation of the neogenin receptor. To understand the functions of RGM-neogenin complexes in vivo, we used gene transfer technology to perturb their expression in the developing neural tube of chick embryos. Surprisingly, neogenin over-expression or RGM down-expression in the neural tube induces apoptosis. Neogenin pro-apoptotic activity in immortalized neuronal cells and in the neural tube is associated with the cleavage of its cytoplasmic domain by caspases. Thus neogenin is a dependence receptor inducing cell death in the absence of RGM, whereas the presence of RGM inhibits this effect."xsd:string
http://purl.uniprot.org/citations/15258591http://purl.org/dc/terms/identifier"doi:10.1038/ncb1157"xsd:string
http://purl.uniprot.org/citations/15258591http://purl.uniprot.org/core/author"Matsunaga E."xsd:string
http://purl.uniprot.org/citations/15258591http://purl.uniprot.org/core/author"Strittmatter S.M."xsd:string
http://purl.uniprot.org/citations/15258591http://purl.uniprot.org/core/author"Mehlen P."xsd:string
http://purl.uniprot.org/citations/15258591http://purl.uniprot.org/core/author"Tauszig-Delamasure S."xsd:string
http://purl.uniprot.org/citations/15258591http://purl.uniprot.org/core/author"Mueller B.K."xsd:string
http://purl.uniprot.org/citations/15258591http://purl.uniprot.org/core/author"Chedotal A."xsd:string
http://purl.uniprot.org/citations/15258591http://purl.uniprot.org/core/author"Monnier P.P."xsd:string
http://purl.uniprot.org/citations/15258591http://purl.uniprot.org/core/date"2004"xsd:gYear
http://purl.uniprot.org/citations/15258591http://purl.uniprot.org/core/name"Nat Cell Biol"xsd:string
http://purl.uniprot.org/citations/15258591http://purl.uniprot.org/core/pages"749-755"xsd:string
http://purl.uniprot.org/citations/15258591http://purl.uniprot.org/core/title"RGM and its receptor neogenin regulate neuronal survival."xsd:string
http://purl.uniprot.org/citations/15258591http://purl.uniprot.org/core/volume"6"xsd:string
http://purl.uniprot.org/citations/15258591http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/15258591
http://purl.uniprot.org/citations/15258591http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/15258591
http://purl.uniprot.org/uniprot/#_Q6ZVN8-mappedCitation-15258591http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/15258591
http://purl.uniprot.org/uniprot/#_Q6NW40-mappedCitation-15258591http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/15258591
http://purl.uniprot.org/uniprot/#_Q8JG54-mappedCitation-15258591http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/15258591
http://purl.uniprot.org/uniprot/#_Q90610-mappedCitation-15258591http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/15258591
http://purl.uniprot.org/uniprot/#_Q92859-mappedCitation-15258591http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/15258591
http://purl.uniprot.org/uniprot/#_Q96B86-mappedCitation-15258591http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/15258591
http://purl.uniprot.org/uniprot/Q6NW40http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/15258591
http://purl.uniprot.org/uniprot/Q96B86http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/15258591