| http://purl.uniprot.org/citations/15259020 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15259020 | http://www.w3.org/2000/01/rdf-schema#comment | "The role of the invariant chain (Ii), an MHC class II-associated chaperone, in B cell development is controversial. Ii deficient mice (Ii(-/-) mice) show a defect in B cell development. This defect has been attributed to the absence of a fragment liberated from the Ii by intramembranous proteolysis. It was proposed that this fragment is required for activation of the NF-kappaB pathway as a means of controlling B cell maturation. The opposing view holds that defects in the assembly of MHC class II molecules result in impaired B cell development. Here we demonstrate that a lack of Ii indeed causes defects in B cell development, with fewer mature B cells in the periphery as previously reported, but that in a compound-mutant from which both Ii and all MHC class II subunits are absent, B cell development is normal. We suggest that neither Ii itself, nor the MHC class II products are required for normal B cell development."xsd:string |
| http://purl.uniprot.org/citations/15259020 | http://purl.org/dc/terms/identifier | "doi:10.1002/eji.200425246"xsd:string |
| http://purl.uniprot.org/citations/15259020 | http://purl.uniprot.org/core/author | "Kraus M."xsd:string |
| http://purl.uniprot.org/citations/15259020 | http://purl.uniprot.org/core/author | "Ploegh H.L."xsd:string |
| http://purl.uniprot.org/citations/15259020 | http://purl.uniprot.org/core/author | "Maehr R."xsd:string |
| http://purl.uniprot.org/citations/15259020 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15259020 | http://purl.uniprot.org/core/name | "Eur J Immunol"xsd:string |
| http://purl.uniprot.org/citations/15259020 | http://purl.uniprot.org/core/pages | "2230-2236"xsd:string |
| http://purl.uniprot.org/citations/15259020 | http://purl.uniprot.org/core/title | "Mice deficient in invariant-chain and MHC class II exhibit a normal mature B2 cell compartment."xsd:string |
| http://purl.uniprot.org/citations/15259020 | http://purl.uniprot.org/core/volume | "34"xsd:string |
| http://purl.uniprot.org/citations/15259020 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15259020 |
| http://purl.uniprot.org/citations/15259020 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15259020 |
| http://purl.uniprot.org/uniprot/#_Q3U4Q8-mappedCitation-15259020 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15259020 |
| http://purl.uniprot.org/uniprot/#_P04441-mappedCitation-15259020 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15259020 |
| http://purl.uniprot.org/uniprot/#_Q545Y5-mappedCitation-15259020 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15259020 |
| http://purl.uniprot.org/uniprot/Q545Y5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15259020 |
| http://purl.uniprot.org/uniprot/P04441 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15259020 |
| http://purl.uniprot.org/uniprot/Q3U4Q8 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15259020 |