| http://purl.uniprot.org/citations/15260990 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15260990 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15260990 | http://www.w3.org/2000/01/rdf-schema#comment | "An important signaling pathway to the actin cytoskeleton links the Rho family GTPase Cdc42 to the actin-nucleating Arp2/3 complex through N-WASP. Nevertheless, these previously identified components are not sufficient to mediate Cdc42-induced actin polymerization in a physiological context. In this paper, we describe the biochemical purification of Toca-1 (transducer of Cdc42-dependent actin assembly) as an essential component of the Cdc42 pathway. Toca-1 binds both N-WASP and Cdc42 and is a member of the evolutionarily conserved PCH protein family. Toca-1 promotes actin nucleation by activating the N-WASP-WIP/CR16 complex, the predominant form of N-WASP in cells. Thus, the cooperative actions of two distinct Cdc42 effectors, the N-WASP-WIP complex and Toca-1, are required for Cdc42-induced actin assembly. These findings represent a significantly revised view of Cdc42-signaling and shed light on the pathogenesis of Wiskott-Aldrich syndrome."xsd:string |
| http://purl.uniprot.org/citations/15260990 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2004.06.027"xsd:string |
| http://purl.uniprot.org/citations/15260990 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2004.06.027"xsd:string |
| http://purl.uniprot.org/citations/15260990 | http://purl.uniprot.org/core/author | "Gygi S.P."xsd:string |
| http://purl.uniprot.org/citations/15260990 | http://purl.uniprot.org/core/author | "Gygi S.P."xsd:string |
| http://purl.uniprot.org/citations/15260990 | http://purl.uniprot.org/core/author | "Li J."xsd:string |
| http://purl.uniprot.org/citations/15260990 | http://purl.uniprot.org/core/author | "Li J."xsd:string |
| http://purl.uniprot.org/citations/15260990 | http://purl.uniprot.org/core/author | "Ma L."xsd:string |
| http://purl.uniprot.org/citations/15260990 | http://purl.uniprot.org/core/author | "Ma L."xsd:string |
| http://purl.uniprot.org/citations/15260990 | http://purl.uniprot.org/core/author | "Kirschner M.W."xsd:string |
| http://purl.uniprot.org/citations/15260990 | http://purl.uniprot.org/core/author | "Kirschner M.W."xsd:string |
| http://purl.uniprot.org/citations/15260990 | http://purl.uniprot.org/core/author | "Ho H.-Y.H."xsd:string |
| http://purl.uniprot.org/citations/15260990 | http://purl.uniprot.org/core/author | "Ho H.-Y.H."xsd:string |
| http://purl.uniprot.org/citations/15260990 | http://purl.uniprot.org/core/author | "Rohatgi R."xsd:string |
| http://purl.uniprot.org/citations/15260990 | http://purl.uniprot.org/core/author | "Rohatgi R."xsd:string |
| http://purl.uniprot.org/citations/15260990 | http://purl.uniprot.org/core/author | "Lebensohn A.M."xsd:string |
| http://purl.uniprot.org/citations/15260990 | http://purl.uniprot.org/core/author | "Lebensohn A.M."xsd:string |
| http://purl.uniprot.org/citations/15260990 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15260990 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15260990 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/15260990 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/15260990 | http://purl.uniprot.org/core/pages | "203-216"xsd:string |
| http://purl.uniprot.org/citations/15260990 | http://purl.uniprot.org/core/pages | "203-216"xsd:string |