| http://purl.uniprot.org/citations/15265042 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15265042 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15265042 | http://www.w3.org/2000/01/rdf-schema#comment | "Propionate is used to protect bread and animal feed from moulds. The mode of action of this short-chain fatty acid was studied using Aspergillus nidulans as a model organism. The filamentous fungus is able to grow slowly on propionate, which is oxidized to acetyl-CoA via propionyl-CoA, methylcitrate and pyruvate. Propionate inhibits growth of A. nidulans on glucose but not on acetate; the latter was shown to inhibit propionate oxidation. When grown on glucose a methylcitrate synthase deletion mutant is much more sensitive towards the presence of propionate in the medium as compared to the wild-type and accumulates 10-fold higher levels of propionyl-CoA, which inhibits CoA-dependent enzymes such as pyruvate dehydrogenase, succinyl-CoA synthetase and ATP citrate lyase. The most important inhibition is that of pyruvate dehydrogenase, as this affects glucose and propionate metabolism directly. In contrast, the blocked succinyl-CoA synthetase can be circumvented by a succinyl-CoA:acetate/propionate CoA-transferase, whereas ATP citrate lyase is required only for biosynthetic purposes. In addition, data are presented that correlate inhibition of fungal polyketide synthesis by propionyl-CoA with the accumulation of this CoA-derivative. A possible toxicity of propionyl-CoA for humans in diseases such as propionic acidaemia and methylmalonic aciduria is also discussed."xsd:string |
| http://purl.uniprot.org/citations/15265042 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1432-1033.2004.04255.x"xsd:string |
| http://purl.uniprot.org/citations/15265042 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1432-1033.2004.04255.x"xsd:string |
| http://purl.uniprot.org/citations/15265042 | http://purl.uniprot.org/core/author | "Buckel W."xsd:string |
| http://purl.uniprot.org/citations/15265042 | http://purl.uniprot.org/core/author | "Buckel W."xsd:string |
| http://purl.uniprot.org/citations/15265042 | http://purl.uniprot.org/core/author | "Brock M."xsd:string |
| http://purl.uniprot.org/citations/15265042 | http://purl.uniprot.org/core/author | "Brock M."xsd:string |
| http://purl.uniprot.org/citations/15265042 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15265042 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15265042 | http://purl.uniprot.org/core/name | "Eur. J. Biochem."xsd:string |
| http://purl.uniprot.org/citations/15265042 | http://purl.uniprot.org/core/name | "Eur. J. Biochem."xsd:string |
| http://purl.uniprot.org/citations/15265042 | http://purl.uniprot.org/core/pages | "3227-3241"xsd:string |
| http://purl.uniprot.org/citations/15265042 | http://purl.uniprot.org/core/pages | "3227-3241"xsd:string |
| http://purl.uniprot.org/citations/15265042 | http://purl.uniprot.org/core/title | "On the mechanism of action of the antifungal agent propionate."xsd:string |
| http://purl.uniprot.org/citations/15265042 | http://purl.uniprot.org/core/title | "On the mechanism of action of the antifungal agent propionate."xsd:string |
| http://purl.uniprot.org/citations/15265042 | http://purl.uniprot.org/core/volume | "271"xsd:string |
| http://purl.uniprot.org/citations/15265042 | http://purl.uniprot.org/core/volume | "271"xsd:string |
| http://purl.uniprot.org/citations/15265042 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15265042 |
| http://purl.uniprot.org/citations/15265042 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15265042 |
| http://purl.uniprot.org/citations/15265042 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15265042 |
| http://purl.uniprot.org/citations/15265042 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15265042 |
| http://purl.uniprot.org/uniprot/Q9TEM3 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/15265042 |
| http://purl.uniprot.org/uniprot/Q9TEM3#attribution-911AA370726D3B45FFDE9C6C23CF3B4A | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15265042 |