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| http://purl.uniprot.org/citations/15266551 | http://www.w3.org/2000/01/rdf-schema#comment | "The role of 5-HT2 receptors in the regulation of acetylcholine (ACh) release was examined in the medial prefrontal cortex and dorsal hippocampus using in vivo microdialysis. The 5-HT(2A/2C) agonist +/-1-(2,5-dimethoxy-4-iodophenyl) -2-aminopropane hydrochloride (DOI) (1 and 2 mg/kg, i.p.) significantly increased the extracellular concentration of ACh in both brain regions, and this response was attenuated in rats treated with the 5-HT(2A/2B/2C) antagonist LY-53,857 (3 mg/kg, i.p.). Treatment with LY-53,857 alone did not significantly alter ACh release in either brain region The 5-HT(2C) agonist 6-chloro-2-(1-piperazinyl)-pyrazine) (MK-212) (5 mg/kg, i.p.) significantly enhanced the release of ACh in both the prefrontal cortex and hippocampus, whereas the 5-HT2 agonist mescaline (10 mg/kg, i.p.) produced a 2-fold increase in ACh release only in the prefrontal cortex. Intracortical, but not intrahippocampal, infusion of DOI (100 microM) significantly enhanced the release of ACh, and intracortical infusion of LY-53,857 (100 microM) significantly attenuated this response. These results suggest that the release of ACh in the prefrontal cortex and hippocampus is influenced by 5-HT2 receptor mechanisms. The increase in release of ACh induced by DOI in the prefrontal cortex, but not in the hippocampus, appears to be due to 5-HT2 receptor mechanisms localized within this brain region. Furthermore, it appears that the prefrontal cortex is more sensitive than the dorsal hippocampus to the stimulatory effect of 5-HT2 agonists on ACh release."xsd:string |
| http://purl.uniprot.org/citations/15266551 | http://purl.org/dc/terms/identifier | "doi:10.1002/syn.20054"xsd:string |
| http://purl.uniprot.org/citations/15266551 | http://purl.uniprot.org/core/author | "Nair S.G."xsd:string |
| http://purl.uniprot.org/citations/15266551 | http://purl.uniprot.org/core/author | "Gudelsky G.A."xsd:string |
| http://purl.uniprot.org/citations/15266551 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15266551 | http://purl.uniprot.org/core/name | "Synapse"xsd:string |
| http://purl.uniprot.org/citations/15266551 | http://purl.uniprot.org/core/pages | "202-207"xsd:string |
| http://purl.uniprot.org/citations/15266551 | http://purl.uniprot.org/core/title | "Activation of 5-HT2 receptors enhances the release of acetylcholine in the prefrontal cortex and hippocampus of the rat."xsd:string |
| http://purl.uniprot.org/citations/15266551 | http://purl.uniprot.org/core/volume | "53"xsd:string |
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