| http://purl.uniprot.org/citations/15271968 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15271968 | http://www.w3.org/2000/01/rdf-schema#comment | "Candidate genes for amelogenesis imperfecta (AI) and dentinogenesis imperfecta (DI) are located on 4q21 in humans. We tested our hypothesis that mutations in the portion of mouse chromosome 5 corresponding to human chromosome 4q21 would cause enamel and dentin abnormalities. Male C3H mice were injected with ethylnitrosourea (ENU). Within a dominant ENU mutagenesis screen, a mouse mutant was isolated with an abnormal tooth enamel (ATE) phenotype. The structure and ultrastructure of teeth were studied. The mutation was located on mouse chromosome 5 in an interval of 9 cM between markers D5Mit18 and D5Mit10. Homozygotic mutants showed total enamel aplasia with exposed dentinal tubules, while heterozygotic mutants showed a significant reduction in enamel width. Dentin of mutant mice showed a reduced content of mature collagen cross-links. We were able to demonstrate that a mutation on chromosome 5 corresponding to human chromosome 4q21 can cause amelogenesis imperfecta and changes in dentin composition."xsd:string |
| http://purl.uniprot.org/citations/15271968 | http://purl.org/dc/terms/identifier | "doi:10.1177/154405910408300805"xsd:string |
| http://purl.uniprot.org/citations/15271968 | http://purl.uniprot.org/core/author | "Seedorf H."xsd:string |
| http://purl.uniprot.org/citations/15271968 | http://purl.uniprot.org/core/author | "Fuchs H."xsd:string |
| http://purl.uniprot.org/citations/15271968 | http://purl.uniprot.org/core/author | "Reis A."xsd:string |
| http://purl.uniprot.org/citations/15271968 | http://purl.uniprot.org/core/author | "Hrabe de Angelis M."xsd:string |
| http://purl.uniprot.org/citations/15271968 | http://purl.uniprot.org/core/author | "Acil Y."xsd:string |
| http://purl.uniprot.org/citations/15271968 | http://purl.uniprot.org/core/author | "Albers H.K."xsd:string |
| http://purl.uniprot.org/citations/15271968 | http://purl.uniprot.org/core/author | "Grundner-Culemann E."xsd:string |
| http://purl.uniprot.org/citations/15271968 | http://purl.uniprot.org/core/author | "Springer I.N."xsd:string |
| http://purl.uniprot.org/citations/15271968 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15271968 | http://purl.uniprot.org/core/name | "J Dent Res"xsd:string |
| http://purl.uniprot.org/citations/15271968 | http://purl.uniprot.org/core/pages | "608-612"xsd:string |
| http://purl.uniprot.org/citations/15271968 | http://purl.uniprot.org/core/title | "Amelogenesis imperfecta in a new animal model--a mutation in chromosome 5 (human 4q21)."xsd:string |
| http://purl.uniprot.org/citations/15271968 | http://purl.uniprot.org/core/volume | "83"xsd:string |
| http://purl.uniprot.org/citations/15271968 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15271968 |
| http://purl.uniprot.org/citations/15271968 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15271968 |
| http://purl.uniprot.org/uniprot/O55196#attribution-3DDD09EF6A7FFC5E8EB5ABEB6D660EBC | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15271968 |
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| http://purl.uniprot.org/uniprot/#_A0A0G2JGL7-mappedCitation-15271968 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15271968 |
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| http://purl.uniprot.org/uniprot/#_A0A0J9YU60-mappedCitation-15271968 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15271968 |
| http://purl.uniprot.org/uniprot/#_E9Q8Z0-mappedCitation-15271968 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15271968 |
| http://purl.uniprot.org/uniprot/#_E9Q984-mappedCitation-15271968 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15271968 |