| http://purl.uniprot.org/citations/15271982 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15271982 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15271982 | http://www.w3.org/2000/01/rdf-schema#comment | "Nucling is a novel protein isolated from murine embryonal carcinoma cells with an up-regulated expression during cardiac muscle differentiation. We show here that Nucling was up-regulated by proapoptotic stimuli and important for the induction of apoptosis after cytotoxic stress. We further demonstrated that overexpressed Nucling was able to induce apoptosis. In Nucling-deficient cells, the expression levels of Apaf-1 and cytochrome c, which are the major components of an apoptosis-promoting complex named apoptosome, were both down-regulated under cellular stress. A deficiency of Nucling also conferred resistance to apoptotic stress on the cell. After UV irradiation, Nucling was shown to reside in an Apaf-1/pro-caspase-9 complex, suggesting that Nucling might be a key molecule for the formation and maintenance of this complex. Nucling induced translocation of Apaf-1 to the nucleus, thereby distributing the Nucling/Apaf-1/pro-caspase-9 complex to the nuclear fraction. These findings suggest that Nucling recruits and transports the apoptosome complex during stress-induced apoptosis."xsd:string |
| http://purl.uniprot.org/citations/15271982 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m402902200"xsd:string |
| http://purl.uniprot.org/citations/15271982 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m402902200"xsd:string |
| http://purl.uniprot.org/citations/15271982 | http://purl.uniprot.org/core/author | "Fukui K."xsd:string |
| http://purl.uniprot.org/citations/15271982 | http://purl.uniprot.org/core/author | "Fukui K."xsd:string |
| http://purl.uniprot.org/citations/15271982 | http://purl.uniprot.org/core/author | "Liu L."xsd:string |
| http://purl.uniprot.org/citations/15271982 | http://purl.uniprot.org/core/author | "Liu L."xsd:string |
| http://purl.uniprot.org/citations/15271982 | http://purl.uniprot.org/core/author | "Matsumoto M."xsd:string |
| http://purl.uniprot.org/citations/15271982 | http://purl.uniprot.org/core/author | "Matsumoto M."xsd:string |
| http://purl.uniprot.org/citations/15271982 | http://purl.uniprot.org/core/author | "Shimada H."xsd:string |
| http://purl.uniprot.org/citations/15271982 | http://purl.uniprot.org/core/author | "Shimada H."xsd:string |
| http://purl.uniprot.org/citations/15271982 | http://purl.uniprot.org/core/author | "Sakai T."xsd:string |
| http://purl.uniprot.org/citations/15271982 | http://purl.uniprot.org/core/author | "Sakai T."xsd:string |
| http://purl.uniprot.org/citations/15271982 | http://purl.uniprot.org/core/author | "Mak T.W."xsd:string |
| http://purl.uniprot.org/citations/15271982 | http://purl.uniprot.org/core/author | "Mak T.W."xsd:string |
| http://purl.uniprot.org/citations/15271982 | http://purl.uniprot.org/core/author | "Ishimura K."xsd:string |
| http://purl.uniprot.org/citations/15271982 | http://purl.uniprot.org/core/author | "Ishimura K."xsd:string |
| http://purl.uniprot.org/citations/15271982 | http://purl.uniprot.org/core/author | "Kaji R."xsd:string |
| http://purl.uniprot.org/citations/15271982 | http://purl.uniprot.org/core/author | "Kaji R."xsd:string |
| http://purl.uniprot.org/citations/15271982 | http://purl.uniprot.org/core/author | "Mitani T."xsd:string |
| http://purl.uniprot.org/citations/15271982 | http://purl.uniprot.org/core/author | "Mitani T."xsd:string |
| http://purl.uniprot.org/citations/15271982 | http://purl.uniprot.org/core/author | "Mukai-Sakai R."xsd:string |
| http://purl.uniprot.org/citations/15271982 | http://purl.uniprot.org/core/author | "Mukai-Sakai R."xsd:string |