| http://purl.uniprot.org/citations/15272004 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15272004 | http://www.w3.org/2000/01/rdf-schema#comment | "The cardiac slow delayed rectifier potassium channel (IKs), comprised of (KCNQ1) and beta (KCNE1) subunits, is regulated by sympathetic nervous stimulation, with activation of beta-adrenergic receptors PKA phosphorylating IKs channels. We examined the effects of 2-adrenergic receptors (beta2-AR) on IKs in cardiac ventricular myocytes from transgenic mice expressing fusion proteins of IKs subunits and hbeta2-ARs. KCNQ1 and beta2-ARs were localized to the same subcellular regions, sharing intimate localization within nanometers of each other. In IKs/B2-AR myocytes, IKs density was increased, and activation shifted in the hyperpolarizing direction; IKs was not further modulated by exposure to isoproterenol, and KCNQ1 was found to be PKA-phosphorylated. Conversely, beta2-AR overexpression did not affect L-type calcium channel current (ICaL) under basal conditions with ICaL remaining responsive to cAMP. These data indicate intimate association of KCNQ1 and beta2-ARs and that beta2-AR signaling can modulate the function of IKs channels under conditions of increased beta2-AR expression, even in the absence of exogenous beta-AR agonist."xsd:string |
| http://purl.uniprot.org/citations/15272004 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m406010200"xsd:string |
| http://purl.uniprot.org/citations/15272004 | http://purl.uniprot.org/core/author | "Kass R.S."xsd:string |
| http://purl.uniprot.org/citations/15272004 | http://purl.uniprot.org/core/author | "Kurokawa J."xsd:string |
| http://purl.uniprot.org/citations/15272004 | http://purl.uniprot.org/core/author | "Marks A.R."xsd:string |
| http://purl.uniprot.org/citations/15272004 | http://purl.uniprot.org/core/author | "Reiken S."xsd:string |
| http://purl.uniprot.org/citations/15272004 | http://purl.uniprot.org/core/author | "Dilly K.W."xsd:string |
| http://purl.uniprot.org/citations/15272004 | http://purl.uniprot.org/core/author | "Lederer W.J."xsd:string |
| http://purl.uniprot.org/citations/15272004 | http://purl.uniprot.org/core/author | "Terrenoire C."xsd:string |
| http://purl.uniprot.org/citations/15272004 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15272004 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/15272004 | http://purl.uniprot.org/core/pages | "40778-40787"xsd:string |
| http://purl.uniprot.org/citations/15272004 | http://purl.uniprot.org/core/title | "Overexpression of beta2-adrenergic receptors cAMP-dependent protein kinase phosphorylates and modulates slow delayed rectifier potassium channels expressed in murine heart: evidence for receptor/channel co-localization."xsd:string |
| http://purl.uniprot.org/citations/15272004 | http://purl.uniprot.org/core/volume | "279"xsd:string |
| http://purl.uniprot.org/citations/15272004 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15272004 |
| http://purl.uniprot.org/citations/15272004 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15272004 |
| http://purl.uniprot.org/uniprot/#_A0A087WQE3-mappedCitation-15272004 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15272004 |
| http://purl.uniprot.org/uniprot/#_A0A087WNY7-mappedCitation-15272004 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15272004 |
| http://purl.uniprot.org/uniprot/#_A0A087WPA8-mappedCitation-15272004 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15272004 |
| http://purl.uniprot.org/uniprot/#_A0A087WPJ2-mappedCitation-15272004 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15272004 |
| http://purl.uniprot.org/uniprot/#_A0A087WRU8-mappedCitation-15272004 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15272004 |
| http://purl.uniprot.org/uniprot/#_A0A087WRK7-mappedCitation-15272004 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15272004 |
| http://purl.uniprot.org/uniprot/#_P97414-mappedCitation-15272004 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15272004 |
| http://purl.uniprot.org/uniprot/#_Q3UWF6-mappedCitation-15272004 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15272004 |