| http://purl.uniprot.org/citations/15273742 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15273742 | http://www.w3.org/2000/01/rdf-schema#comment | "Mice deficient in TNF-alpha (TNF-alpha(-/-) mice) are resistant to skin carcinogenesis and expression of MMP-9 is inhibited in TNF-alpha(-/-) mice during skin tumour development. In the early stages of tumour promotion, MMP-9 protein initially localized to the follicular epidermis but subsequently began to accumulate in the interfollicular epidermis of wild-type but not TNF-alpha(-/-) mice. Inhibition of TNF-alpha or MMP-9 function reduced keratinocyte migration in vitro. In addition, a deficiency of TNF-alpha delayed re-epithelialization in vivo and this correlated with reduced MMP-9 expression. Collectively, these data suggest that MMP-9 regulates keratinocyte migration in a TNF-alpha-dependent manner. Expression profiling of genes that control cell adhesion and migration revealed markedly lower levels of the integrin subunits alphav and beta6 in TNF-alpha(-/-) compared with wild-type keratinocytes in vitro. alphavbeta6 expression was upregulated by keratinocytes in vitro and during tumour promotion in vivo in a TNF-alpha-dependent manner. Furthermore, alphavbeta6 blockade significantly inhibited keratinocyte migration and TNF-alpha-stimulated MMP-9 expression in vitro. These data illustrate a novel TNF-alpha-dependent mechanism for the control of alphavbeta6 expression and suggest one pathway for TNF-alpha regulation of MMP-9. Increased MMP-9 and alphavbeta6 expression may stimulate epithelial cell migration during tumour formation and may be one mechanism whereby TNF-alpha acts as an endogenous tumour promoter."xsd:string |
| http://purl.uniprot.org/citations/15273742 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.onc.1207915"xsd:string |
| http://purl.uniprot.org/citations/15273742 | http://purl.uniprot.org/core/author | "Marshall J.F."xsd:string |
| http://purl.uniprot.org/citations/15273742 | http://purl.uniprot.org/core/author | "Moore R.J."xsd:string |
| http://purl.uniprot.org/citations/15273742 | http://purl.uniprot.org/core/author | "Scott K.A."xsd:string |
| http://purl.uniprot.org/citations/15273742 | http://purl.uniprot.org/core/author | "Thompson R.G."xsd:string |
| http://purl.uniprot.org/citations/15273742 | http://purl.uniprot.org/core/author | "Balkwill F.R."xsd:string |
| http://purl.uniprot.org/citations/15273742 | http://purl.uniprot.org/core/author | "Robinson S.C."xsd:string |
| http://purl.uniprot.org/citations/15273742 | http://purl.uniprot.org/core/author | "Arnott C.H."xsd:string |
| http://purl.uniprot.org/citations/15273742 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15273742 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/15273742 | http://purl.uniprot.org/core/pages | "6954-6966"xsd:string |
| http://purl.uniprot.org/citations/15273742 | http://purl.uniprot.org/core/title | "TNF-alpha regulates epithelial expression of MMP-9 and integrin alphavbeta6 during tumour promotion. A role for TNF-alpha in keratinocyte migration?"xsd:string |
| http://purl.uniprot.org/citations/15273742 | http://purl.uniprot.org/core/volume | "23"xsd:string |
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