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Background

Several case-control studies have found an association between chronic beryllium disease (CBD) and HLA-DPB1 gene variants. However, the relationship between HLA-DPB1 and beryllium sensitization, and whether the presence of one or two HLA-DPB1(Glu69) alleles is differentially associated with CBD and beryllium sensitization have not been completely resolved.

Methods

Restriction fragment length polymorphism (RFLP) analysis was used to address these questions in a large population-based cohort consisting of 884 beryllium workers (90 with CBD, 64 beryllium sensitized).

Results

HLA-DPB1(Glu69) was associated with both CBD (OR = 9.4; 95% CI = 5.4, 16.6) and sensitization (OR = 3.3, 95% CI = 1.9, 5.9). Further, workers with CBD and sensitization were more likely to be homozygous HLA-DPB1(Glu69) compared to workers without disease or sensitization (P < 0.001).

Conclusions

Follow-up of this cohort, scrutiny of HLA-DPB1 haplotypes, and evaluation of gene-environment and gene-gene interactions will be important for fully understanding the immunogenetic nature of this occupational disease."xsd:string
http://purl.uniprot.org/citations/15273960http://purl.org/dc/terms/identifier"doi:10.1002/ajim.20045"xsd:string
http://purl.uniprot.org/citations/15273960http://purl.uniprot.org/core/author"Weston A."xsd:string
http://purl.uniprot.org/citations/15273960http://purl.uniprot.org/core/author"Ensey J.S."xsd:string
http://purl.uniprot.org/citations/15273960http://purl.uniprot.org/core/author"McCanlies E.C."xsd:string
http://purl.uniprot.org/citations/15273960http://purl.uniprot.org/core/author"Kreiss K."xsd:string
http://purl.uniprot.org/citations/15273960http://purl.uniprot.org/core/author"Schuler C.R."xsd:string
http://purl.uniprot.org/citations/15273960http://purl.uniprot.org/core/date"2004"xsd:gYear
http://purl.uniprot.org/citations/15273960http://purl.uniprot.org/core/name"Am J Ind Med"xsd:string
http://purl.uniprot.org/citations/15273960http://purl.uniprot.org/core/pages"95-103"xsd:string
http://purl.uniprot.org/citations/15273960http://purl.uniprot.org/core/title"The association between HLA-DPB1Glu69 and chronic beryllium disease and beryllium sensitization."xsd:string
http://purl.uniprot.org/citations/15273960http://purl.uniprot.org/core/volume"46"xsd:string
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