| http://purl.uniprot.org/citations/15276215 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15276215 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15276215 | http://www.w3.org/2000/01/rdf-schema#comment | "We have determined the entire DNA sequence of pLVPK, which is a 219-kb virulence plasmid harbored in a bacteremic isolate of Klebsiella pneumoniae. A total of 251 open reading frames (ORFs) were annotated, of which 37% have homologous genes of known function, 31% match the hypothetical genes in the GenBank database, and the remaining 32% are novel sequences. The obvious virulence-associated genes carried by the plasmid are the capsular polysaccharide synthesis regulator rmpA and its homolog rmpA2, and multiple iron-acquisition systems, including iucABCDiutA and iroBCDN siderophore gene clusters, Mesorhizobium loti fepBC ABC-type transporter, and Escherichia coli fecIRA, which encodes a Fur-dependent regulatory system for iron uptake. In addition, several gene clusters homologous with copper, silver, lead, and tellurite resistance genes of other bacteria were also identified. Identification of a replication origin consisting of a repA gene lying in between two sets of iterons suggests that the replication of pLVPK is iteron-controlled and the iterons are the binding sites for the repA to initiate replication and maintain copy number of the plasmid. Genes homologous with E. coli sopA/sopB and parA/parB with nearby direct DNA repeats were also identified indicating the presence of an F plasmid-like partitioning system. Finally, the presence of 13 insertion sequences located mostly at the boundaries of the aforementioned gene clusters suggests that pLVPK was derived from a sequential assembly of various horizontally acquired DNA fragments."xsd:string |
| http://purl.uniprot.org/citations/15276215 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.gene.2004.05.008"xsd:string |
| http://purl.uniprot.org/citations/15276215 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.gene.2004.05.008"xsd:string |
| http://purl.uniprot.org/citations/15276215 | http://purl.uniprot.org/core/author | "Chen Y.-T."xsd:string |
| http://purl.uniprot.org/citations/15276215 | http://purl.uniprot.org/core/author | "Chen Y.-T."xsd:string |
| http://purl.uniprot.org/citations/15276215 | http://purl.uniprot.org/core/author | "Tsai S.F."xsd:string |
| http://purl.uniprot.org/citations/15276215 | http://purl.uniprot.org/core/author | "Tsai S.-F."xsd:string |
| http://purl.uniprot.org/citations/15276215 | http://purl.uniprot.org/core/author | "Tsai S.-F."xsd:string |
| http://purl.uniprot.org/citations/15276215 | http://purl.uniprot.org/core/author | "Peng H.-L."xsd:string |
| http://purl.uniprot.org/citations/15276215 | http://purl.uniprot.org/core/author | "Peng H.-L."xsd:string |
| http://purl.uniprot.org/citations/15276215 | http://purl.uniprot.org/core/author | "Chang H.Y."xsd:string |
| http://purl.uniprot.org/citations/15276215 | http://purl.uniprot.org/core/author | "Chang H.-Y."xsd:string |
| http://purl.uniprot.org/citations/15276215 | http://purl.uniprot.org/core/author | "Chang H.-Y."xsd:string |
| http://purl.uniprot.org/citations/15276215 | http://purl.uniprot.org/core/author | "Peng H.L."xsd:string |
| http://purl.uniprot.org/citations/15276215 | http://purl.uniprot.org/core/author | "Chen Y.T."xsd:string |
| http://purl.uniprot.org/citations/15276215 | http://purl.uniprot.org/core/author | "Lai Y.-C."xsd:string |
| http://purl.uniprot.org/citations/15276215 | http://purl.uniprot.org/core/author | "Lai Y.-C."xsd:string |
| http://purl.uniprot.org/citations/15276215 | http://purl.uniprot.org/core/author | "Pan C.-C."xsd:string |
| http://purl.uniprot.org/citations/15276215 | http://purl.uniprot.org/core/author | "Pan C.-C."xsd:string |
| http://purl.uniprot.org/citations/15276215 | http://purl.uniprot.org/core/author | "Lai Y.C."xsd:string |
| http://purl.uniprot.org/citations/15276215 | http://purl.uniprot.org/core/author | "Pan C.C."xsd:string |
| http://purl.uniprot.org/citations/15276215 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15276215 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |