| http://purl.uniprot.org/citations/15280205 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15280205 | http://www.w3.org/2000/01/rdf-schema#comment | "Interleukin-15 (IL-15) is a gamma-common cytokine that plays an important role in the development, survival, and proliferation of natural killer (NK), NK T, and CD8+ T-cells. We administered IL-15 to recipients of an allogeneic bone marrow transplantation (allo BMT) to determine its effects on immune reconstitution. Posttransplantation IL-15 administration significantly increased donor-derived CD8+ T (mostly CD122(+)CD44(+)CD8+ T-cells), NK, and NK T-cells at day +28 in young and old recipients of allo BMT. This was associated with enhanced T-cell and NK-cell function. IL-15 stimulated homeostatic proliferation of donor CD8+ T-cells in recipients of carboxyfluorescein diacetate succinimidyl ester-labeled donor T-cell infusions. Posttransplantation IL-15 administration also resulted in a decrease in apoptotic CD8+ T-cells, an increase in Bcl-2-expressing CD8+ T-cells, and an increase in the fraction of Ki67+ proliferative NK and CD8+ T-cells in recipients of allo BMT. IL-15 did not exacerbate graft-versus-host disease (GVHD) in recipients of T-cell-depleted BMT but could aggravate GVHD in some cases in recipients of a T-cell-repleted BMT. Finally, we found that IL-15 administration could enhance graft-versus-leukemia activity. In conclusion, IL-15 can be administered safely to recipients of a T-cell-depleted allo BMT to enhance CD8+ T, NK, and NK T-cell reconstitution."xsd:string |
| http://purl.uniprot.org/citations/15280205 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2003-09-3344"xsd:string |
| http://purl.uniprot.org/citations/15280205 | http://purl.uniprot.org/core/author | "Willis L.M."xsd:string |
| http://purl.uniprot.org/citations/15280205 | http://purl.uniprot.org/core/author | "Kochman A."xsd:string |
| http://purl.uniprot.org/citations/15280205 | http://purl.uniprot.org/core/author | "van den Brink M.R."xsd:string |
| http://purl.uniprot.org/citations/15280205 | http://purl.uniprot.org/core/author | "Alpdogan O."xsd:string |
| http://purl.uniprot.org/citations/15280205 | http://purl.uniprot.org/core/author | "Eng J.M."xsd:string |
| http://purl.uniprot.org/citations/15280205 | http://purl.uniprot.org/core/author | "Hubbard V.M."xsd:string |
| http://purl.uniprot.org/citations/15280205 | http://purl.uniprot.org/core/author | "Muriglan S.J."xsd:string |
| http://purl.uniprot.org/citations/15280205 | http://purl.uniprot.org/core/author | "Terwey T.H."xsd:string |
| http://purl.uniprot.org/citations/15280205 | http://purl.uniprot.org/core/author | "Tjoe K.H."xsd:string |
| http://purl.uniprot.org/citations/15280205 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15280205 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/15280205 | http://purl.uniprot.org/core/pages | "865-873"xsd:string |
| http://purl.uniprot.org/citations/15280205 | http://purl.uniprot.org/core/title | "Interleukin-15 enhances immune reconstitution after allogeneic bone marrow transplantation."xsd:string |
| http://purl.uniprot.org/citations/15280205 | http://purl.uniprot.org/core/volume | "105"xsd:string |
| http://purl.uniprot.org/citations/15280205 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15280205 |
| http://purl.uniprot.org/citations/15280205 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15280205 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GQZ2-mappedCitation-15280205 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15280205 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GQZ8-mappedCitation-15280205 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15280205 |
| http://purl.uniprot.org/uniprot/#_Q1AHQ6-mappedCitation-15280205 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15280205 |
| http://purl.uniprot.org/uniprot/#_Q1AHQ7-mappedCitation-15280205 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15280205 |
| http://purl.uniprot.org/uniprot/#_P48346-mappedCitation-15280205 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15280205 |
| http://purl.uniprot.org/uniprot/#_Q3U1Z6-mappedCitation-15280205 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15280205 |