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| http://purl.uniprot.org/citations/15280428 | http://www.w3.org/2000/01/rdf-schema#comment | "Protein folding in the mitochondria is assisted by nuclear-encoded compartment-specific chaperones but regulation of the expression of their encoding genes is poorly understood. We found that the mitochondrial matrix HSP70 and HSP60 chaperones, encoded by the Caenorhabditis elegans hsp-6 and hsp-60 genes, were selectively activated by perturbations that impair assembly of multi-subunit mitochondrial complexes or by RNAi of genes encoding mitochondrial chaperones or proteases, which lead to defective protein folding and processing in the organelle. hsp-6 and hsp-60 induction was specific to perturbed mitochondrial protein handling, as neither heat-shock nor endoplasmic reticulum stress nor manipulations that impair mitochondrial steps in intermediary metabolism or ATP synthesis activated the mitochondrial chaperone genes. These observations support the existence of a mitochondrial unfolded protein response that couples mitochondrial chaperone gene expression to changes in the protein handling environment in the organelle."xsd:string |
| http://purl.uniprot.org/citations/15280428 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.01275"xsd:string |
| http://purl.uniprot.org/citations/15280428 | http://purl.uniprot.org/core/author | "Yoneda T."xsd:string |
| http://purl.uniprot.org/citations/15280428 | http://purl.uniprot.org/core/author | "Harding H.P."xsd:string |
| http://purl.uniprot.org/citations/15280428 | http://purl.uniprot.org/core/author | "Ron D."xsd:string |
| http://purl.uniprot.org/citations/15280428 | http://purl.uniprot.org/core/author | "Clark S.G."xsd:string |
| http://purl.uniprot.org/citations/15280428 | http://purl.uniprot.org/core/author | "Benedetti C."xsd:string |
| http://purl.uniprot.org/citations/15280428 | http://purl.uniprot.org/core/author | "Urano F."xsd:string |
| http://purl.uniprot.org/citations/15280428 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15280428 | http://purl.uniprot.org/core/name | "J Cell Sci"xsd:string |
| http://purl.uniprot.org/citations/15280428 | http://purl.uniprot.org/core/pages | "4055-4066"xsd:string |
| http://purl.uniprot.org/citations/15280428 | http://purl.uniprot.org/core/title | "Compartment-specific perturbation of protein handling activates genes encoding mitochondrial chaperones."xsd:string |
| http://purl.uniprot.org/citations/15280428 | http://purl.uniprot.org/core/volume | "117"xsd:string |
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