| http://purl.uniprot.org/citations/15282274 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15282274 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15282274 | http://www.w3.org/2000/01/rdf-schema#comment | "Alpha-synuclein contributes to the pathogenesis of Parkinson's disease (PD), but its precise role in the disorder and its normal function remain poorly understood. Consistent with a presumed role in neurotransmitter release and its prominent deposition in the dystrophic neurites of PD, alpha-synuclein localizes almost exclusively to the nerve terminal. In brain extracts, however, alpha-synuclein behaves as a soluble, monomeric protein. Using a binding assay to characterize the association of alpha-synuclein with cell membranes, we find that alpha-synuclein binds saturably and with high affinity to characteristic intracellular structures that double label for components of lipid rafts. Biochemical analysis demonstrates the interaction of alpha-synuclein with detergent-resistant membranes and reveals a shift in electrophoretic mobility of the raft-associated protein. In addition, the A30P mutation associated with PD disrupts the interaction of alpha-synuclein with lipid rafts. Furthermore, we find that both the A30P mutation and raft disruption redistribute alpha-synuclein away from synapses, indicating an important role for raft association in the normal function of alpha-synuclein and its role in the pathogenesis of PD."xsd:string |
| http://purl.uniprot.org/citations/15282274 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.1594-04.2004"xsd:string |
| http://purl.uniprot.org/citations/15282274 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.1594-04.2004"xsd:string |
| http://purl.uniprot.org/citations/15282274 | http://purl.uniprot.org/core/author | "Kubo S."xsd:string |
| http://purl.uniprot.org/citations/15282274 | http://purl.uniprot.org/core/author | "Kubo S."xsd:string |
| http://purl.uniprot.org/citations/15282274 | http://purl.uniprot.org/core/author | "Nakamura K."xsd:string |
| http://purl.uniprot.org/citations/15282274 | http://purl.uniprot.org/core/author | "Nakamura K."xsd:string |
| http://purl.uniprot.org/citations/15282274 | http://purl.uniprot.org/core/author | "Edwards R.H."xsd:string |
| http://purl.uniprot.org/citations/15282274 | http://purl.uniprot.org/core/author | "Edwards R.H."xsd:string |
| http://purl.uniprot.org/citations/15282274 | http://purl.uniprot.org/core/author | "Anthony M.D."xsd:string |
| http://purl.uniprot.org/citations/15282274 | http://purl.uniprot.org/core/author | "Anthony M.D."xsd:string |
| http://purl.uniprot.org/citations/15282274 | http://purl.uniprot.org/core/author | "Fortin D.L."xsd:string |
| http://purl.uniprot.org/citations/15282274 | http://purl.uniprot.org/core/author | "Fortin D.L."xsd:string |
| http://purl.uniprot.org/citations/15282274 | http://purl.uniprot.org/core/author | "Troyer M.D."xsd:string |
| http://purl.uniprot.org/citations/15282274 | http://purl.uniprot.org/core/author | "Troyer M.D."xsd:string |
| http://purl.uniprot.org/citations/15282274 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15282274 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15282274 | http://purl.uniprot.org/core/name | "J. Neurosci."xsd:string |
| http://purl.uniprot.org/citations/15282274 | http://purl.uniprot.org/core/name | "J. Neurosci."xsd:string |
| http://purl.uniprot.org/citations/15282274 | http://purl.uniprot.org/core/pages | "6715-6723"xsd:string |
| http://purl.uniprot.org/citations/15282274 | http://purl.uniprot.org/core/pages | "6715-6723"xsd:string |
| http://purl.uniprot.org/citations/15282274 | http://purl.uniprot.org/core/title | "Lipid rafts mediate the synaptic localization of alpha-synuclein."xsd:string |
| http://purl.uniprot.org/citations/15282274 | http://purl.uniprot.org/core/title | "Lipid rafts mediate the synaptic localization of alpha-synuclein."xsd:string |