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http://purl.uniprot.org/citations/15283758http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/15283758http://www.w3.org/2000/01/rdf-schema#comment"

Aim

By crossing aquaporin 1 (AQP1)-/- and adenosine 1 receptor (A1AR)-/-mice, we generated an animal model that combines a proximal tubular absorption defect with absence of tubuloglomerular feedback (TGF) regulation of glomerular filtration rate (GFR). The aim of studies in these animals was to determine whether a TGF-induced reduction of GFR is a prerequisite for preventing potentially fatal fluid losses.

Methods and results

In contrast to AQP1 deficient mice, AQP1/A1AR-/-mice were found to have a normal GFR. TGF responses were abolished in these animals, in contrast to AQP1-/-mice in which TGF responses of single nephron glomerular filtration rate (SNGFR) were left-shifted. Proximal tubule fluid absorption in AQP1/A1AR-/-mice was reduced to levels previously reported for AQP1-/-mice. However, SNGFR was significantly higher in AQP1/A1AR-/- than AQP1-/-mice (10.6 +/- 0.8 nL min(-1) vs. 5.9 +/-0.7 nL min(-1)). As a consequence of the normal GFR and the reduced proximal reabsorption distal fluid delivery was markedly higher in the double knockout compared with normal or AQP1-/- mice (5.5 +/- 0.5 nL min(-1) vs. 2.35 +/-0.3 nL min(-1) in AQP1-/-). Despite the approximate doubling of distal fluid and Cl delivery, AQP1/A1AR-/-mice have a normal salt excretion, normal arterial blood pressure, and only a small increase in plasma renin concentration.

Conclusion

The ability to compensate for proximal tubule malabsorption without a TGF-induced reduction of GFR attests to a remarkable adaptability of distal tubule transport mechanisms."xsd:string
http://purl.uniprot.org/citations/15283758http://purl.org/dc/terms/identifier"doi:10.1111/j.1365-201x.2004.01318.x"xsd:string
http://purl.uniprot.org/citations/15283758http://purl.uniprot.org/core/author"Huang Y."xsd:string
http://purl.uniprot.org/citations/15283758http://purl.uniprot.org/core/author"Hashimoto S."xsd:string
http://purl.uniprot.org/citations/15283758http://purl.uniprot.org/core/author"Briggs J."xsd:string
http://purl.uniprot.org/citations/15283758http://purl.uniprot.org/core/author"Schnermann J."xsd:string
http://purl.uniprot.org/citations/15283758http://purl.uniprot.org/core/author"Mizel D."xsd:string
http://purl.uniprot.org/citations/15283758http://purl.uniprot.org/core/date"2004"xsd:gYear
http://purl.uniprot.org/citations/15283758http://purl.uniprot.org/core/name"Acta Physiol Scand"xsd:string
http://purl.uniprot.org/citations/15283758http://purl.uniprot.org/core/pages"455-462"xsd:string
http://purl.uniprot.org/citations/15283758http://purl.uniprot.org/core/title"Compensation of proximal tubule malabsorption in AQP1-deficient mice without TGF-mediated reduction of GFR."xsd:string
http://purl.uniprot.org/citations/15283758http://purl.uniprot.org/core/volume"181"xsd:string
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