| http://purl.uniprot.org/citations/15286806 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15286806 | http://www.w3.org/2000/01/rdf-schema#comment | "Mechanical injury to the skin results in activation of the complement component C3 and release of the anaphylatoxin C3a. C3a binds to a seven-transmembrane G protein-coupled receptor, C3aR. We used C3aR(-/-) mice to examine the role of C3a in a mouse model of allergic inflammation induced by epicutaneous sensitization with OVA. C3aR(-/-) mice exhibited an exaggerated Th2 response to epicutaneous but not to intraperitoneal sensitization with OVA, as evidenced by significantly elevated levels of serum OVA-specific IgG1 and significantly increased secretion of the Th2 cytokines IL-4, IL-5, and IL-10 by antigen-stimulated splenocytes. Presentation of OVA peptide by C3aR(-/-) APCs caused significantly more IL-4 and IL-5 secretion by T cells from OVA-T cell receptor (OVA-TCR) transgenic mice compared with presentation by WT APCs. C3a inhibited the ability of splenocytes, but not of highly purified T cells, to secrete Th2 cytokines in response to TCR ligation. This inhibition was mediated by IL-12 secreted by APCs in response to C3a. These results suggest that C3a-C3aR interactions inhibit the ability of APCs to drive Th2 cell differentiation in response to epicutaneously introduced antigen and may have important implications for allergic skin diseases."xsd:string |
| http://purl.uniprot.org/citations/15286806 | http://purl.org/dc/terms/identifier | "doi:10.1172/jci19082"xsd:string |
| http://purl.uniprot.org/citations/15286806 | http://purl.uniprot.org/core/author | "Lu B."xsd:string |
| http://purl.uniprot.org/citations/15286806 | http://purl.uniprot.org/core/author | "Gerard C."xsd:string |
| http://purl.uniprot.org/citations/15286806 | http://purl.uniprot.org/core/author | "Kawamoto S."xsd:string |
| http://purl.uniprot.org/citations/15286806 | http://purl.uniprot.org/core/author | "Geha R.S."xsd:string |
| http://purl.uniprot.org/citations/15286806 | http://purl.uniprot.org/core/author | "Humbles A.A."xsd:string |
| http://purl.uniprot.org/citations/15286806 | http://purl.uniprot.org/core/author | "Oettgen H."xsd:string |
| http://purl.uniprot.org/citations/15286806 | http://purl.uniprot.org/core/author | "Laouini D."xsd:string |
| http://purl.uniprot.org/citations/15286806 | http://purl.uniprot.org/core/author | "Brodeur S."xsd:string |
| http://purl.uniprot.org/citations/15286806 | http://purl.uniprot.org/core/author | "Yalcindag A."xsd:string |
| http://purl.uniprot.org/citations/15286806 | http://purl.uniprot.org/core/author | "Bryce P."xsd:string |
| http://purl.uniprot.org/citations/15286806 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15286806 | http://purl.uniprot.org/core/name | "J Clin Invest"xsd:string |
| http://purl.uniprot.org/citations/15286806 | http://purl.uniprot.org/core/pages | "399-407"xsd:string |
| http://purl.uniprot.org/citations/15286806 | http://purl.uniprot.org/core/title | "The anaphylatoxin C3a downregulates the Th2 response to epicutaneously introduced antigen."xsd:string |
| http://purl.uniprot.org/citations/15286806 | http://purl.uniprot.org/core/volume | "114"xsd:string |
| http://purl.uniprot.org/citations/15286806 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15286806 |
| http://purl.uniprot.org/citations/15286806 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15286806 |
| http://purl.uniprot.org/uniprot/#_O09047-mappedCitation-15286806 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15286806 |
| http://purl.uniprot.org/uniprot/#_Q5U7A4-mappedCitation-15286806 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15286806 |
| http://purl.uniprot.org/uniprot/#_Q3U4N3-mappedCitation-15286806 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15286806 |
| http://purl.uniprot.org/uniprot/#_Q8C6R2-mappedCitation-15286806 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15286806 |
| http://purl.uniprot.org/uniprot/Q3U4N3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15286806 |