| http://purl.uniprot.org/citations/15287000 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15287000 | http://www.w3.org/2000/01/rdf-schema#comment | "TEF-1 transcription factors regulate gene expression in skeletal muscle but are not muscle-specific. Instead, TEF-1 factors rely on the muscle-specific cofactor Vestigial-like 2 (Vgl-2), a protein related to Drosophila vestigial. Previously, we showed that Vgl-2 promotes skeletal muscle differentiation and activates muscle-specific promoters. However, the mechanism whereby Vgl-2 regulates TEF-1 factors and the requirement for Vgl-2 for muscle-specific gene expression were not known. In Drosophila, vestigial alters DNA binding specificity of the TEF-1 homolog scalloped to drive wing and flight muscle-specific gene expression. Here, gel mobility shift assays show that Vgl-2 differentially affects DNA binding of different TEF-1 factors. Using an antisense morpholino, we blocked the expression of Vgl-2 and a muscle-specific gene in the myogenic C2C12 cell line and in chick embryos by electroporation. These results demonstrate that Vgl-2 is required for muscle gene expression, in part by switching DNA binding of TEF-1 factors during muscle differentiation."xsd:string |
| http://purl.uniprot.org/citations/15287000 | http://purl.org/dc/terms/identifier | "doi:10.1002/gene.20055"xsd:string |
| http://purl.uniprot.org/citations/15287000 | http://purl.uniprot.org/core/author | "Maeda T."xsd:string |
| http://purl.uniprot.org/citations/15287000 | http://purl.uniprot.org/core/author | "Chen H.H."xsd:string |
| http://purl.uniprot.org/citations/15287000 | http://purl.uniprot.org/core/author | "Stewart A.F."xsd:string |
| http://purl.uniprot.org/citations/15287000 | http://purl.uniprot.org/core/author | "Mullett S.J."xsd:string |
| http://purl.uniprot.org/citations/15287000 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15287000 | http://purl.uniprot.org/core/name | "Genesis"xsd:string |
| http://purl.uniprot.org/citations/15287000 | http://purl.uniprot.org/core/pages | "273-279"xsd:string |
| http://purl.uniprot.org/citations/15287000 | http://purl.uniprot.org/core/title | "Transcription cofactor Vgl-2 is required for skeletal muscle differentiation."xsd:string |
| http://purl.uniprot.org/citations/15287000 | http://purl.uniprot.org/core/volume | "39"xsd:string |
| http://purl.uniprot.org/citations/15287000 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15287000 |
| http://purl.uniprot.org/citations/15287000 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15287000 |
| http://purl.uniprot.org/uniprot/#_A3KN78-mappedCitation-15287000 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15287000 |
| http://purl.uniprot.org/uniprot/#_F7B3M8-mappedCitation-15287000 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15287000 |
| http://purl.uniprot.org/uniprot/#_Q8BR79-mappedCitation-15287000 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15287000 |
| http://purl.uniprot.org/uniprot/#_Q3UFP5-mappedCitation-15287000 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15287000 |
| http://purl.uniprot.org/uniprot/#_Q8BGW8-mappedCitation-15287000 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15287000 |
| http://purl.uniprot.org/uniprot/#_P30051-mappedCitation-15287000 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15287000 |
| http://purl.uniprot.org/uniprot/#_Q3USK5-mappedCitation-15287000 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15287000 |
| http://purl.uniprot.org/uniprot/#_Q6PAQ8-mappedCitation-15287000 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15287000 |
| http://purl.uniprot.org/uniprot/#_Q80W05-mappedCitation-15287000 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15287000 |
| http://purl.uniprot.org/uniprot/Q6PAQ8 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15287000 |
| http://purl.uniprot.org/uniprot/Q80W05 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15287000 |