| http://purl.uniprot.org/citations/15288471 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15288471 | http://www.w3.org/2000/01/rdf-schema#comment | "Background/aimsIn alcoholic hepatitis (AH), soluble TNF alpha receptor-1 (sTNF-R1) is increased. Elevated TNF alpha predicts mortality, but infection influences TNF alpha values. In patients with AH, we determined the prognostic value of TNF alpha, sTNF-R1, and lipopolysaccharide binding protein (LBP) and CD14, both involved in endotoxemia-associated inflammation.MethodsOne hundred and eight cirrhotic patients (Pugh score 10 [6-13]) and biopsy-proven AH (Maddrey's DF <32: n=46; > or =32: n=62) without associated infection were included within 8 days of admission and followed-up for 3 months. Cytokines were measured using specific immunoassays. Patients with severe AH received steroids.ResultsTwenty four patients died at a median time of 35 days (range: 3-89). The overall survival was 78%. Multivariate Cox regression analysis showed that sTNF-R1 was an independent predictor of mortality, (OR 4.33: 95% CI [1.12-16.75]). Pugh's score (P=0.618), Maddrey's DF (P=0.182), creatinine (P=0.197), TNF alpha (P=0.319), LBP (P=0.362), and CD14 (P=0.347) were not related to survival.ConclusionsIn patients with AH, sTNF-R1 measured at admission is an independent predictor of survival at 3 months. Provided that TNF-R1 mediates the cytotoxic actions of TNFalpha, these results support the concept of dysregulated TNF alpha metabolism in AH."xsd:string |
| http://purl.uniprot.org/citations/15288471 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.jhep.2004.04.028"xsd:string |
| http://purl.uniprot.org/citations/15288471 | http://purl.uniprot.org/core/author | "Rubbia-Brandt L."xsd:string |
| http://purl.uniprot.org/citations/15288471 | http://purl.uniprot.org/core/author | "Hadengue A."xsd:string |
| http://purl.uniprot.org/citations/15288471 | http://purl.uniprot.org/core/author | "Frossard J.L."xsd:string |
| http://purl.uniprot.org/citations/15288471 | http://purl.uniprot.org/core/author | "Giostra E."xsd:string |
| http://purl.uniprot.org/citations/15288471 | http://purl.uniprot.org/core/author | "Bresson-Hadni S."xsd:string |
| http://purl.uniprot.org/citations/15288471 | http://purl.uniprot.org/core/author | "Spahr L."xsd:string |
| http://purl.uniprot.org/citations/15288471 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15288471 | http://purl.uniprot.org/core/name | "J Hepatol"xsd:string |
| http://purl.uniprot.org/citations/15288471 | http://purl.uniprot.org/core/pages | "229-234"xsd:string |
| http://purl.uniprot.org/citations/15288471 | http://purl.uniprot.org/core/title | "Soluble TNF-R1, but not tumor necrosis factor alpha, predicts the 3-month mortality in patients with alcoholic hepatitis."xsd:string |
| http://purl.uniprot.org/citations/15288471 | http://purl.uniprot.org/core/volume | "41"xsd:string |
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