| http://purl.uniprot.org/citations/15289464 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15289464 | http://www.w3.org/2000/01/rdf-schema#comment | "CCAAT/enhancer-binding proteins, C/EBPalpha and C/EBPbeta, are required for fat cell differentiation and maturation. Previous studies showed that replacement of C/EBPalpha with C/EBPbeta, generating the beta/beta alleles in the mouse genome, prevents lipid accumulation in white adipose tissue (WAT). In this study, beta/beta mice lived longer and had higher energy expenditure than their control littermates due to increased WAT energy oxidation. The WAT of beta/beta mice was enriched with metabolically active, thermogenic mitochondria known for energy burning. The beta/beta allele exerted its effect through the elevated expression of the G protein alpha stimulatory subunit (Galphas) in WAT. Galphas, when overexpressed in fat-laden 3T3-L1 cells, stimulated mitochondrial biogenesis similar to that seen in the WAT of beta/beta mice, and effectively diminished the stored lipid pool."xsd:string |
| http://purl.uniprot.org/citations/15289464 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.1213104"xsd:string |
| http://purl.uniprot.org/citations/15289464 | http://purl.uniprot.org/core/author | "Lee Y.H."xsd:string |
| http://purl.uniprot.org/citations/15289464 | http://purl.uniprot.org/core/author | "Lin W.D."xsd:string |
| http://purl.uniprot.org/citations/15289464 | http://purl.uniprot.org/core/author | "Huang S.Y."xsd:string |
| http://purl.uniprot.org/citations/15289464 | http://purl.uniprot.org/core/author | "Chiu C.H."xsd:string |
| http://purl.uniprot.org/citations/15289464 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15289464 | http://purl.uniprot.org/core/name | "Genes Dev"xsd:string |
| http://purl.uniprot.org/citations/15289464 | http://purl.uniprot.org/core/pages | "1970-1975"xsd:string |
| http://purl.uniprot.org/citations/15289464 | http://purl.uniprot.org/core/title | "Effect of a C/EBP gene replacement on mitochondrial biogenesis in fat cells."xsd:string |
| http://purl.uniprot.org/citations/15289464 | http://purl.uniprot.org/core/volume | "18"xsd:string |
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