| http://purl.uniprot.org/citations/15289613 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15289613 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15289613 | http://www.w3.org/2000/01/rdf-schema#comment | "HER-1 is a secreted protein that promotes male development in the nematode Caenorhabditis elegans. HER-1 inhibits the function of TRA-2A, a multipass integral membrane protein thought to serve as its receptor. We report here the 1.5-A crystal structure of HER-1. The structure was solved by the multiwavelength anomalous diffraction method by using selenomethionyl-substituted HER-1 produced in Chinese hamster ovary cells. The HER-1 structure consists of two all-helical domains and is not closely homologous to any known structure. Sites of amino acid substitutions known to impair HER-1 function were mapped on the HER-1 structure and classified according to the likely mechanism by which they affect HER-1 activity. A subset of these and other amino acid substitutions on the HER-1 surface were assayed for their ability to disrupt interactions between HER-1 and TRA-2A-expressing cells, and a localized region on the HER-1 surface important for mediating this interaction was identified."xsd:string |
| http://purl.uniprot.org/citations/15289613 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0402559101"xsd:string |
| http://purl.uniprot.org/citations/15289613 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0402559101"xsd:string |
| http://purl.uniprot.org/citations/15289613 | http://purl.uniprot.org/core/author | "Geisbrecht B.V."xsd:string |
| http://purl.uniprot.org/citations/15289613 | http://purl.uniprot.org/core/author | "Geisbrecht B.V."xsd:string |
| http://purl.uniprot.org/citations/15289613 | http://purl.uniprot.org/core/author | "Dann C.E. III"xsd:string |
| http://purl.uniprot.org/citations/15289613 | http://purl.uniprot.org/core/author | "Dann C.E. III"xsd:string |
| http://purl.uniprot.org/citations/15289613 | http://purl.uniprot.org/core/author | "Leahy D.J."xsd:string |
| http://purl.uniprot.org/citations/15289613 | http://purl.uniprot.org/core/author | "Leahy D.J."xsd:string |
| http://purl.uniprot.org/citations/15289613 | http://purl.uniprot.org/core/author | "Hamaoka B.Y."xsd:string |
| http://purl.uniprot.org/citations/15289613 | http://purl.uniprot.org/core/author | "Hamaoka B.Y."xsd:string |
| http://purl.uniprot.org/citations/15289613 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15289613 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15289613 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/15289613 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/15289613 | http://purl.uniprot.org/core/pages | "11673-11678"xsd:string |
| http://purl.uniprot.org/citations/15289613 | http://purl.uniprot.org/core/pages | "11673-11678"xsd:string |
| http://purl.uniprot.org/citations/15289613 | http://purl.uniprot.org/core/title | "Crystal structure of Caenorhabditis elegans HER-1 and characterization of the interaction between HER-1 and TRA-2A."xsd:string |
| http://purl.uniprot.org/citations/15289613 | http://purl.uniprot.org/core/title | "Crystal structure of Caenorhabditis elegans HER-1 and characterization of the interaction between HER-1 and TRA-2A."xsd:string |
| http://purl.uniprot.org/citations/15289613 | http://purl.uniprot.org/core/volume | "101"xsd:string |
| http://purl.uniprot.org/citations/15289613 | http://purl.uniprot.org/core/volume | "101"xsd:string |
| http://purl.uniprot.org/citations/15289613 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15289613 |
| http://purl.uniprot.org/citations/15289613 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15289613 |