| http://purl.uniprot.org/citations/15294938 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15294938 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15294938 | http://www.w3.org/2000/01/rdf-schema#comment | "CD6 is a cell surface receptor expressed on immature thymocytes and mature T and B1a lymphocytes. The ultimate function of CD6 has not been deciphered yet, but much evidence supports a role for CD6 in T cell activation and differentiation. In this study, we show that a fraction of CD6 molecules physically associates with the TCR/CD3 complex by coimmunoprecipitation, cocapping, and fluorescence resonance energy transfer experiments. Image analysis of Ag-specific T-APC conjugates demonstrated that CD6 and its ligand, activated leukocyte cell adhesion molecule (CD166), colocalize with TCR/CD3 at the center of the immunological synapse, the so-called central supramolecular activation cluster. The addition of a soluble rCD6 form significantly reduced the number of mature Ag-specific T-APC conjugates, indicating that CD6 mediates early cell-cell interactions needed for immunological synapse maturation to proceed. This was in agreement with the dose-dependent inhibition of CD3-mediated T cell proliferation induced by soluble rCD6. Taken together, our data illustrate the important role played by the intra- and intercellular molecular interactions mediated by CD6 during T cell activation and proliferation processes."xsd:string |
| http://purl.uniprot.org/citations/15294938 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.173.4.2262"xsd:string |
| http://purl.uniprot.org/citations/15294938 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.173.4.2262"xsd:string |
| http://purl.uniprot.org/citations/15294938 | http://purl.uniprot.org/core/author | "Calvo M."xsd:string |
| http://purl.uniprot.org/citations/15294938 | http://purl.uniprot.org/core/author | "Calvo M."xsd:string |
| http://purl.uniprot.org/citations/15294938 | http://purl.uniprot.org/core/author | "Mittelbrunn M."xsd:string |
| http://purl.uniprot.org/citations/15294938 | http://purl.uniprot.org/core/author | "Mittelbrunn M."xsd:string |
| http://purl.uniprot.org/citations/15294938 | http://purl.uniprot.org/core/author | "Enrich C."xsd:string |
| http://purl.uniprot.org/citations/15294938 | http://purl.uniprot.org/core/author | "Enrich C."xsd:string |
| http://purl.uniprot.org/citations/15294938 | http://purl.uniprot.org/core/author | "Farnos M."xsd:string |
| http://purl.uniprot.org/citations/15294938 | http://purl.uniprot.org/core/author | "Farnos M."xsd:string |
| http://purl.uniprot.org/citations/15294938 | http://purl.uniprot.org/core/author | "Gimferrer I."xsd:string |
| http://purl.uniprot.org/citations/15294938 | http://purl.uniprot.org/core/author | "Gimferrer I."xsd:string |
| http://purl.uniprot.org/citations/15294938 | http://purl.uniprot.org/core/author | "Lozano F."xsd:string |
| http://purl.uniprot.org/citations/15294938 | http://purl.uniprot.org/core/author | "Lozano F."xsd:string |
| http://purl.uniprot.org/citations/15294938 | http://purl.uniprot.org/core/author | "Sanchez-Madrid F."xsd:string |
| http://purl.uniprot.org/citations/15294938 | http://purl.uniprot.org/core/author | "Sanchez-Madrid F."xsd:string |
| http://purl.uniprot.org/citations/15294938 | http://purl.uniprot.org/core/author | "Sarrias M.R."xsd:string |
| http://purl.uniprot.org/citations/15294938 | http://purl.uniprot.org/core/author | "Sarrias M.R."xsd:string |
| http://purl.uniprot.org/citations/15294938 | http://purl.uniprot.org/core/author | "Vives J."xsd:string |
| http://purl.uniprot.org/citations/15294938 | http://purl.uniprot.org/core/author | "Vives J."xsd:string |
| http://purl.uniprot.org/citations/15294938 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15294938 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |