| http://purl.uniprot.org/citations/15294994 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15294994 | http://www.w3.org/2000/01/rdf-schema#comment | "Several ligands for Toll IL-1R (TIR) family are known to promote stabilization of a subset of short-lived mRNAs containing AU-rich elements (AREs) in their 3' untranslated regions. It is now evident however, that members of the TIR family may use distinct intracellular signaling pathways to achieve a spectrum of biological end points. Using human embryonic kidney 293 cells transfected to express different TIRs we now report that signals initiated through IL-1R1 or TLR4 but not TLR3 can promote the stabilization of unstable chemokine mRNAs. Similar results were obtained when signaling from endogenous receptors was examined using a mouse endothelial cell line (H5V). The ability of TIR family members to stabilize ARE-containing mRNAs results from their differential use of signaling adaptors MyD88, MyD88 adaptor-like protein, Toll receptor IFN-inducing factor (Trif), and Trif-related adaptor molecule. Overexpression of MyD88 or MyD88 adaptor-like protein was able to promote enhanced stability of ARE-containing mRNA, whereas Trif and Trif-related adaptor molecule exhibited markedly reduced capacity. Hence the ability of TIRs to signal stabilization of mRNA appears to be linked to the MyD88-dependent signaling pathway."xsd:string |
| http://purl.uniprot.org/citations/15294994 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.173.4.2755"xsd:string |
| http://purl.uniprot.org/citations/15294994 | http://purl.uniprot.org/core/author | "Li X."xsd:string |
| http://purl.uniprot.org/citations/15294994 | http://purl.uniprot.org/core/author | "Novotny M."xsd:string |
| http://purl.uniprot.org/citations/15294994 | http://purl.uniprot.org/core/author | "Datta S."xsd:string |
| http://purl.uniprot.org/citations/15294994 | http://purl.uniprot.org/core/author | "Hamilton T.A."xsd:string |
| http://purl.uniprot.org/citations/15294994 | http://purl.uniprot.org/core/author | "Tebo J."xsd:string |
| http://purl.uniprot.org/citations/15294994 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15294994 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/15294994 | http://purl.uniprot.org/core/pages | "2755-2761"xsd:string |
| http://purl.uniprot.org/citations/15294994 | http://purl.uniprot.org/core/title | "Toll IL-1 receptors differ in their ability to promote the stabilization of adenosine and uridine-rich elements containing mRNA."xsd:string |
| http://purl.uniprot.org/citations/15294994 | http://purl.uniprot.org/core/volume | "173"xsd:string |
| http://purl.uniprot.org/citations/15294994 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15294994 |
| http://purl.uniprot.org/citations/15294994 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15294994 |
| http://purl.uniprot.org/uniprot/Q99836#attribution-EA461B68B47B4DB71B6DF9E9273DAD5D | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15294994 |
| http://purl.uniprot.org/uniprot/P58753#attribution-EA461B68B47B4DB71B6DF9E9273DAD5D | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15294994 |