| http://purl.uniprot.org/citations/15296743 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15296743 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15296743 | http://www.w3.org/2000/01/rdf-schema#comment | "The C-terminal G3 domains of lecticans mediate crosslinking to diverse extracellular matrix (ECM) proteins during ECM assembly, through their C-type lectin (CLD) subdomains. The structure of the rat aggrecan CLD in a Ca(2+)-dependent complex with fibronectin type III repeats 3-5 of rat tenascin-R provides detailed support for such crosslinking. The CLD loops bind Ca2+ like other CLDs, but no carbohydrate binding is observed or possible. This is thus the first example of a direct Ca(2+)-dependent protein-protein interaction of a CLD. Surprisingly, tenascin-R does not coordinate the Ca2+ ions directly. Electron microscopy confirms that full-length tenascin-R and tenascin-C crosslink hyaluronan-aggrecan complexes. The results are significant for the binding of all lectican CLDs to tenascin-R and tenascin-C. Comparison of the protein interaction surface with that of P-selectin in complex with the PGSL-1 peptide suggests that direct protein-protein interactions of Ca(2+)-binding CLDs may be more widespread than previously appreciated."xsd:string |
| http://purl.uniprot.org/citations/15296743 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.str.2004.05.021"xsd:string |
| http://purl.uniprot.org/citations/15296743 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.str.2004.05.021"xsd:string |
| http://purl.uniprot.org/citations/15296743 | http://purl.uniprot.org/core/author | "Logan D.T."xsd:string |
| http://purl.uniprot.org/citations/15296743 | http://purl.uniprot.org/core/author | "Logan D.T."xsd:string |
| http://purl.uniprot.org/citations/15296743 | http://purl.uniprot.org/core/author | "Morgelin M."xsd:string |
| http://purl.uniprot.org/citations/15296743 | http://purl.uniprot.org/core/author | "Morgelin M."xsd:string |
| http://purl.uniprot.org/citations/15296743 | http://purl.uniprot.org/core/author | "Aspberg A."xsd:string |
| http://purl.uniprot.org/citations/15296743 | http://purl.uniprot.org/core/author | "Aspberg A."xsd:string |
| http://purl.uniprot.org/citations/15296743 | http://purl.uniprot.org/core/author | "Olin A.I."xsd:string |
| http://purl.uniprot.org/citations/15296743 | http://purl.uniprot.org/core/author | "Olin A.I."xsd:string |
| http://purl.uniprot.org/citations/15296743 | http://purl.uniprot.org/core/author | "Lundell A."xsd:string |
| http://purl.uniprot.org/citations/15296743 | http://purl.uniprot.org/core/author | "Lundell A."xsd:string |
| http://purl.uniprot.org/citations/15296743 | http://purl.uniprot.org/core/author | "al-Karadaghi S."xsd:string |
| http://purl.uniprot.org/citations/15296743 | http://purl.uniprot.org/core/author | "al-Karadaghi S."xsd:string |
| http://purl.uniprot.org/citations/15296743 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15296743 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15296743 | http://purl.uniprot.org/core/name | "Structure"xsd:string |
| http://purl.uniprot.org/citations/15296743 | http://purl.uniprot.org/core/name | "Structure"xsd:string |
| http://purl.uniprot.org/citations/15296743 | http://purl.uniprot.org/core/pages | "1495-1506"xsd:string |
| http://purl.uniprot.org/citations/15296743 | http://purl.uniprot.org/core/pages | "1495-1506"xsd:string |
| http://purl.uniprot.org/citations/15296743 | http://purl.uniprot.org/core/title | "Structural basis for interactions between tenascins and lectican C-type lectin domains: evidence for a crosslinking role for tenascins."xsd:string |
| http://purl.uniprot.org/citations/15296743 | http://purl.uniprot.org/core/title | "Structural basis for interactions between tenascins and lectican C-type lectin domains: evidence for a crosslinking role for tenascins."xsd:string |