http://purl.uniprot.org/citations/15297164 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/15297164 | http://www.w3.org/2000/01/rdf-schema#comment | "ObjectiveBAG-1 has anti-apoptotic actions and is known to bind BCL-2 and steroid receptors. High levels of BAG-1 have been implicated as a prognostic indicator in breast cancer. Whether this observation can be generalized to endometrial cancer remains unknown.MethodsIRB permission was obtained for use of human discarded tissue. Immunohistochemical analyses were performed on: proliferative endometrium (PEM, 6), secretory endometrium (SEM, 28), "low-grade" neoplastic lesions (complex atypical hyperplasia and grade 1 endometrial adenocarcinomas) (19), and "high-grade" cancers (grade 2 and 3 endometrial adenocarcinomas) (13). The level of total BAG-1 and its isoforms was evaluated by Western blot in lysates from Ishikawa cells (grade 1), MFE 296 cells (grade 2), and SK-UT(2) cells (grade 3).ResultsThe proportion of "high-grade" cancers with positive cytoplasmic staining for BAG-1 was higher than that of secretory endometrium (P = 0.006). Additionally, the proportion of specimens with positive staining for nuclear BAG-1 expression was significantly higher among high-grade carcinoma specimens compared to secretory specimens (P = 0.009). A high proportion (91%) of all specimens were positive for BCL-2, limiting the ability to subcategorize the other variables analyzed. There was no relationship between positive nuclear BAG-1 expression and either estrogen receptor (ER) or progesterone receptor (PR) expression. BAG-1 was expressed in the three cell lines evaluated and total BAG-1 level was not different among the different cell lines.ConclusionBAG-1 is expressed in the endometrium. High-grade cancers stain more frequently than secretory endometrium for both cytoplasmic and nuclear BAG-1 expression, perhaps indicating an association between expression of BAG-1 and prognosis."xsd:string |
http://purl.uniprot.org/citations/15297164 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ygyno.2004.04.026"xsd:string |
http://purl.uniprot.org/citations/15297164 | http://purl.uniprot.org/core/author | "Moriyama T."xsd:string |
http://purl.uniprot.org/citations/15297164 | http://purl.uniprot.org/core/author | "Duska L.R."xsd:string |
http://purl.uniprot.org/citations/15297164 | http://purl.uniprot.org/core/author | "Littell R.D."xsd:string |
http://purl.uniprot.org/citations/15297164 | http://purl.uniprot.org/core/author | "Lynch M.P."xsd:string |
http://purl.uniprot.org/citations/15297164 | http://purl.uniprot.org/core/author | "Rueda B.R."xsd:string |
http://purl.uniprot.org/citations/15297164 | http://purl.uniprot.org/core/author | "Oliva E."xsd:string |
http://purl.uniprot.org/citations/15297164 | http://purl.uniprot.org/core/author | "Debernardo R."xsd:string |
http://purl.uniprot.org/citations/15297164 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
http://purl.uniprot.org/citations/15297164 | http://purl.uniprot.org/core/name | "Gynecol Oncol"xsd:string |
http://purl.uniprot.org/citations/15297164 | http://purl.uniprot.org/core/pages | "289-295"xsd:string |
http://purl.uniprot.org/citations/15297164 | http://purl.uniprot.org/core/title | "BAG-1 expression in normal and neoplastic endometrium."xsd:string |
http://purl.uniprot.org/citations/15297164 | http://purl.uniprot.org/core/volume | "94"xsd:string |
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