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http://purl.uniprot.org/citations/15300630http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/15300630http://www.w3.org/2000/01/rdf-schema#comment"

Objective

To investigate the frequency of microsatellite instability (MSI) and loss of heterozygosity (LOH) at human leucocyte antigen(HLA) class I loci in cervical carcinoma and the detailed deletion mapping in this region.

Methods

LOH and MSI of HLA class I genes were analyzed in 30 paired blood and tumor samples by PCR based single-stranded length polymorphism (PCR-SSLP).

Results

Of the 30 cases, 23(76.7%) showed LOH at one or more loci. Higher frequencies of LOH were found at four loci: C3_2_11 (50%), C1_4_4 (37%), C1_2_5 (36.7%), D6S276 (48.3%). MSI was found in 20 out of 30 cases (66.7%).

Conclusion

The data suggest that the LOH and MSI of HLA class I gene might participate in the carcinogenesis of cervical carcinoma. Meanwhile, the minimal deletion region might be defined between C1_2_5 and C3_2_11, thus providing the evidence for cloning the tumor suppressor genes associated with cervical carcinoma."xsd:string
http://purl.uniprot.org/citations/15300630http://purl.uniprot.org/core/author"Zhao M."xsd:string
http://purl.uniprot.org/citations/15300630http://purl.uniprot.org/core/author"Wu X.F."xsd:string
http://purl.uniprot.org/citations/15300630http://purl.uniprot.org/core/author"Rong Y."xsd:string
http://purl.uniprot.org/citations/15300630http://purl.uniprot.org/core/author"Wu X.X."xsd:string
http://purl.uniprot.org/citations/15300630http://purl.uniprot.org/core/author"Chen G.M."xsd:string
http://purl.uniprot.org/citations/15300630http://purl.uniprot.org/core/date"2004"xsd:gYear
http://purl.uniprot.org/citations/15300630http://purl.uniprot.org/core/name"Zhonghua Yi Xue Yi Chuan Xue Za Zhi"xsd:string
http://purl.uniprot.org/citations/15300630http://purl.uniprot.org/core/pages"342-346"xsd:string
http://purl.uniprot.org/citations/15300630http://purl.uniprot.org/core/title"[Microsatellite instability and loss of heterozygosity of human leucocyte antigen class I gene in cervical carcinoma]."xsd:string
http://purl.uniprot.org/citations/15300630http://purl.uniprot.org/core/volume"21"xsd:string
http://purl.uniprot.org/citations/15300630http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/15300630
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