| http://purl.uniprot.org/citations/15302159 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
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| http://purl.uniprot.org/citations/15302159 | http://www.w3.org/2000/01/rdf-schema#comment | "The participation of a divergent mosquito transforming growth factor-beta (TGF-beta) and mammalian TGF-beta1 in the Anopheles stephensi response to malaria parasite development [Infect. Genet. Evol. 1 (2001) 131-141; Infect. Immun. 71 (2003) 3000-3009] suggests that a network of Anopheles TGF-beta ligands and signaling pathways figure prominently in immune defense of this important vector group. To provide a basis for identifying the roles of these proteins in Anopheles innate immunity, we identified six predicted TGF-beta ligand-encoding genes in the Anopheles gambiae genome, including two expressed, diverged copies of 60A, the first evidence of ligand gene duplication outside of chordates. In addition to five predicted type I and II receptors, we identified three Smad genes in the A. gambiae genome that would be predicted to support both TGF-beta/Activin- and bone morphogenetic protein (BMP)-like signaling. All three Smad genes are expressed in an immunocompetent A. stephensi cell line and in the A. stephensi midgut epithelium, confirming that a conserved signaling architecture is in place to support signaling by divergent exogenous and endogenous TGF-beta superfamily proteins."xsd:string |
| http://purl.uniprot.org/citations/15302159 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molimm.2004.06.001"xsd:string |
| http://purl.uniprot.org/citations/15302159 | http://purl.uniprot.org/core/author | "Luckhart S."xsd:string |
| http://purl.uniprot.org/citations/15302159 | http://purl.uniprot.org/core/author | "Luckhart S."xsd:string |
| http://purl.uniprot.org/citations/15302159 | http://purl.uniprot.org/core/author | "Lieber M.J."xsd:string |
| http://purl.uniprot.org/citations/15302159 | http://purl.uniprot.org/core/author | "Lieber M.J."xsd:string |
| http://purl.uniprot.org/citations/15302159 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15302159 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15302159 | http://purl.uniprot.org/core/name | "Mol. Immunol."xsd:string |
| http://purl.uniprot.org/citations/15302159 | http://purl.uniprot.org/core/name | "Mol Immunol"xsd:string |
| http://purl.uniprot.org/citations/15302159 | http://purl.uniprot.org/core/pages | "965-977"xsd:string |
| http://purl.uniprot.org/citations/15302159 | http://purl.uniprot.org/core/pages | "965-977"xsd:string |
| http://purl.uniprot.org/citations/15302159 | http://purl.uniprot.org/core/title | "Transforming growth factor-betas and related gene products in mosquito vectors of human malaria parasites: signaling architecture for immunological crosstalk."xsd:string |
| http://purl.uniprot.org/citations/15302159 | http://purl.uniprot.org/core/title | "Transforming growth factor-betas and related gene products in mosquito vectors of human malaria parasites: signaling architecture for immunological crosstalk."xsd:string |
| http://purl.uniprot.org/citations/15302159 | http://purl.uniprot.org/core/volume | "41"xsd:string |
| http://purl.uniprot.org/citations/15302159 | http://purl.uniprot.org/core/volume | "41"xsd:string |
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| http://purl.uniprot.org/citations/15302159 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15302159 |
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| http://purl.uniprot.org/citations/15302159 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15302159 |
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