| http://purl.uniprot.org/citations/15302600 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15302600 | http://www.w3.org/2000/01/rdf-schema#comment | "Neural stem cells are present in specific regions of the adult central nervous system (CNS). Recent evidence suggests that the ciliary epithelium (CE), a CNS derivative, in the adult mammalian eye, harbors a quiescent population of neural stem cells. Here, we report the identification of c-Kit signaling as one of the regulators of adult CE neural stem cells in vitro. c-Kit receptors are expressed in proliferating adult CE neural stem cells and colocalized with neural progenitor markers. Perturbation of c-Kit signaling influences the self-renewal and differentiation of CE neural stem cells, thus demonstrating the role of c-Kit signaling in the maintenance of these cells. In addition, we observed an influence of c-Kit-mediated signaling on the expression of Notch1, another critical regulator of neural stem cells. Our observations suggest that, given the importance of preservation of a stem cell pool for generating different cell types at different times, multiple signaling pathways act in concert for the maintenance of neural stem cells."xsd:string |
| http://purl.uniprot.org/citations/15302600 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ydbio.2004.05.023"xsd:string |
| http://purl.uniprot.org/citations/15302600 | http://purl.uniprot.org/core/author | "Zhao X."xsd:string |
| http://purl.uniprot.org/citations/15302600 | http://purl.uniprot.org/core/author | "Ahmad I."xsd:string |
| http://purl.uniprot.org/citations/15302600 | http://purl.uniprot.org/core/author | "James J."xsd:string |
| http://purl.uniprot.org/citations/15302600 | http://purl.uniprot.org/core/author | "Das A.V."xsd:string |
| http://purl.uniprot.org/citations/15302600 | http://purl.uniprot.org/core/author | "Rahnenfuhrer J."xsd:string |
| http://purl.uniprot.org/citations/15302600 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15302600 | http://purl.uniprot.org/core/name | "Dev Biol"xsd:string |
| http://purl.uniprot.org/citations/15302600 | http://purl.uniprot.org/core/pages | "87-105"xsd:string |
| http://purl.uniprot.org/citations/15302600 | http://purl.uniprot.org/core/title | "Identification of c-Kit receptor as a regulator of adult neural stem cells in the mammalian eye: interactions with Notch signaling."xsd:string |
| http://purl.uniprot.org/citations/15302600 | http://purl.uniprot.org/core/volume | "273"xsd:string |
| http://purl.uniprot.org/citations/15302600 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15302600 |
| http://purl.uniprot.org/citations/15302600 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15302600 |
| http://purl.uniprot.org/uniprot/A0A0G2JTL4#attribution-62109527E7535E58D85158E557784674 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15302600 |
| http://purl.uniprot.org/uniprot/A6JD00#attribution-62109527E7535E58D85158E557784674 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15302600 |
| http://purl.uniprot.org/uniprot/B7SCJ1#attribution-62109527E7535E58D85158E557784674 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15302600 |
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| http://purl.uniprot.org/uniprot/Q63116#attribution-62109527E7535E58D85158E557784674 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15302600 |
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| http://purl.uniprot.org/uniprot/#_B7SCJ2-mappedCitation-15302600 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15302600 |