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http://purl.uniprot.org/citations/15302849http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/15302849http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/15302849http://www.w3.org/2000/01/rdf-schema#comment"Five Fc receptor homologs (FcRH1-5) possessing inhibitory and/or activating signaling motifs are differentially expressed during B cell differentiation in humans. In this analysis we describe their three mouse orthologs, moFcRH1, moFcRH2 and moFcRH3. The moFcRH genes are located in a chromosome 3 region that is syntenic with the FcRH locus on human chromosome 1. They encode proteins with 2-5 Ig-like domains that share 20-61% extracellular identity with their human counterparts. One moFcRH1 isoform lacks a transmembrane domain as do both moFcRH2 isoforms. The other moFcRH1 isoform and two moFcRH3 isoforms have transmembrane domains and cytoplasmic ITIM and ITAM-like consensus sequences implying their inhibitory or activating signaling potential. Whereas the moFcRH1 and moFcRH3 orthologs are preferentially expressed at different stages in B cell differentiation, the structurally novel moFcRH2 gene is expressed in non-lymphoid tissues. The highly restricted pattern of moFcRH3 expression suggests this member of the phylogenetically conserved FcRH family may have an important immunoregulatory role in marginal zone B cells."xsd:string
http://purl.uniprot.org/citations/15302849http://purl.org/dc/terms/identifier"doi:10.1093/intimm/dxh137"xsd:string
http://purl.uniprot.org/citations/15302849http://purl.org/dc/terms/identifier"doi:10.1093/intimm/dxh137"xsd:string
http://purl.uniprot.org/citations/15302849http://purl.uniprot.org/core/author"Chen C.-C."xsd:string
http://purl.uniprot.org/citations/15302849http://purl.uniprot.org/core/author"Chen C.-C."xsd:string
http://purl.uniprot.org/citations/15302849http://purl.uniprot.org/core/author"Cooper M.D."xsd:string
http://purl.uniprot.org/citations/15302849http://purl.uniprot.org/core/author"Cooper M.D."xsd:string
http://purl.uniprot.org/citations/15302849http://purl.uniprot.org/core/author"Davis R.S."xsd:string
http://purl.uniprot.org/citations/15302849http://purl.uniprot.org/core/author"Davis R.S."xsd:string
http://purl.uniprot.org/citations/15302849http://purl.uniprot.org/core/author"Dennis G. Jr."xsd:string
http://purl.uniprot.org/citations/15302849http://purl.uniprot.org/core/author"Dennis G. Jr."xsd:string
http://purl.uniprot.org/citations/15302849http://purl.uniprot.org/core/author"Stephan R.P."xsd:string
http://purl.uniprot.org/citations/15302849http://purl.uniprot.org/core/author"Stephan R.P."xsd:string
http://purl.uniprot.org/citations/15302849http://purl.uniprot.org/core/date"2004"xsd:gYear
http://purl.uniprot.org/citations/15302849http://purl.uniprot.org/core/date"2004"xsd:gYear
http://purl.uniprot.org/citations/15302849http://purl.uniprot.org/core/name"Int. Immunol."xsd:string
http://purl.uniprot.org/citations/15302849http://purl.uniprot.org/core/name"Int. Immunol."xsd:string
http://purl.uniprot.org/citations/15302849http://purl.uniprot.org/core/pages"1343-1353"xsd:string
http://purl.uniprot.org/citations/15302849http://purl.uniprot.org/core/pages"1343-1353"xsd:string
http://purl.uniprot.org/citations/15302849http://purl.uniprot.org/core/title"Differential B cell expression of mouse Fc receptor homologs."xsd:string
http://purl.uniprot.org/citations/15302849http://purl.uniprot.org/core/title"Differential B cell expression of mouse Fc receptor homologs."xsd:string
http://purl.uniprot.org/citations/15302849http://purl.uniprot.org/core/volume"16"xsd:string
http://purl.uniprot.org/citations/15302849http://purl.uniprot.org/core/volume"16"xsd:string