| http://purl.uniprot.org/citations/15302918 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15302918 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15302918 | http://www.w3.org/2000/01/rdf-schema#comment | "The nuclear orphan receptor TAK1/TR4 functions as a positive as well as a negative regulator of transcription; however, little is known about the factors regulating or mediating its activity. Yeast two-hybrid analysis using the ligand-binding domain (LBD) of TAK1 as bait identified a novel TAK1-interacting protein, referred to as TIP27, which functions as a repressor of TAK1-mediated transactivation. TIP27 is a 27 kDa protein containing two zinc finger motifs. Mammalian two-hybrid analysis showed that TIP27 interacts specifically with TAK1 and not with several other nuclear receptors tested. The region between Asp39 and Lys79 of TIP27, referred to as TAK1-interaction domain (TID), is critical for its interaction with TAK1 while the TAK1-LBD from helix 3 until the C-terminus is required for the optimal interaction with TIP27. Pull-down assays demonstrated that the TIP27 physically interacts with TAK1 and supported the critical importance of the TID. Confocal microscopy showed that in the nucleus, TIP27 and TAK1 co-localize. TIP27 acts as a strong repressor of DR1-dependent transcriptional activation by TAK1. This repression does not involve the inhibition of TAK1 homodimerization or DR1 binding but may be due to an effect on co-activator recruitment by TAK1. Our results indicate that TIP27 functions as a TAK1-selective repressor."xsd:string |
| http://purl.uniprot.org/citations/15302918 | http://purl.org/dc/terms/identifier | "doi:10.1093/nar/gkh741"xsd:string |
| http://purl.uniprot.org/citations/15302918 | http://purl.org/dc/terms/identifier | "doi:10.1093/nar/gkh741"xsd:string |
| http://purl.uniprot.org/citations/15302918 | http://purl.uniprot.org/core/author | "Kim Y.S."xsd:string |
| http://purl.uniprot.org/citations/15302918 | http://purl.uniprot.org/core/author | "Kim Y.S."xsd:string |
| http://purl.uniprot.org/citations/15302918 | http://purl.uniprot.org/core/author | "Nakajima T."xsd:string |
| http://purl.uniprot.org/citations/15302918 | http://purl.uniprot.org/core/author | "Nakajima T."xsd:string |
| http://purl.uniprot.org/citations/15302918 | http://purl.uniprot.org/core/author | "Fujino S."xsd:string |
| http://purl.uniprot.org/citations/15302918 | http://purl.uniprot.org/core/author | "Fujino S."xsd:string |
| http://purl.uniprot.org/citations/15302918 | http://purl.uniprot.org/core/author | "Jetten A.M."xsd:string |
| http://purl.uniprot.org/citations/15302918 | http://purl.uniprot.org/core/author | "Jetten A.M."xsd:string |
| http://purl.uniprot.org/citations/15302918 | http://purl.uniprot.org/core/author | "Nakanishi G."xsd:string |
| http://purl.uniprot.org/citations/15302918 | http://purl.uniprot.org/core/author | "Nakanishi G."xsd:string |
| http://purl.uniprot.org/citations/15302918 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15302918 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15302918 | http://purl.uniprot.org/core/name | "Nucleic Acids Res."xsd:string |
| http://purl.uniprot.org/citations/15302918 | http://purl.uniprot.org/core/name | "Nucleic Acids Res."xsd:string |
| http://purl.uniprot.org/citations/15302918 | http://purl.uniprot.org/core/pages | "4194-4204"xsd:string |
| http://purl.uniprot.org/citations/15302918 | http://purl.uniprot.org/core/pages | "4194-4204"xsd:string |
| http://purl.uniprot.org/citations/15302918 | http://purl.uniprot.org/core/title | "TIP27: a novel repressor of the nuclear orphan receptor TAK1/TR4."xsd:string |
| http://purl.uniprot.org/citations/15302918 | http://purl.uniprot.org/core/title | "TIP27: a novel repressor of the nuclear orphan receptor TAK1/TR4."xsd:string |
| http://purl.uniprot.org/citations/15302918 | http://purl.uniprot.org/core/volume | "32"xsd:string |
| http://purl.uniprot.org/citations/15302918 | http://purl.uniprot.org/core/volume | "32"xsd:string |