| http://purl.uniprot.org/citations/15304216 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15304216 | http://www.w3.org/2000/01/rdf-schema#comment | "Bax inhibitor-1 (BI-1) is an evolutionarily conserved endoplasmic reticulum (ER) protein that suppresses cell death in both animal and plant cells. We characterized mice in which the bi-1 gene was ablated. Cells from BI-1-deficient mice, including fibroblasts, hepatocytes, and neurons, display selective hypersensitivity to apoptosis induced by ER stress agents (thapsigargin, tunicamycin, brefeldin A), but not to stimulators of mitochondrial or TNF/Fas-death receptor apoptosis pathways. Conversely, BI-1 overexpression protects against apoptosis induced by ER stress. BI-1-mediated protection from apoptosis induced by ER stress correlated with inhibition of Bax activation and translocation to mitochondria, preservation of mitochondrial membrane potential, and suppression of caspase activation. BI-1 overexpression also reduces releasable Ca(2+) from the ER. In vivo, bi-1(-/-) mice exhibit increased sensitivity to tissue damage induced by stimuli that trigger ER stress, including stroke and tunicamycin injection. Thus, BI-1 regulates a cell death pathway important for cytopreservation during ER stress."xsd:string |
| http://purl.uniprot.org/citations/15304216 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2004.06.038"xsd:string |
| http://purl.uniprot.org/citations/15304216 | http://purl.uniprot.org/core/author | "Kim H.R."xsd:string |
| http://purl.uniprot.org/citations/15304216 | http://purl.uniprot.org/core/author | "Xu C."xsd:string |
| http://purl.uniprot.org/citations/15304216 | http://purl.uniprot.org/core/author | "Krajewski S."xsd:string |
| http://purl.uniprot.org/citations/15304216 | http://purl.uniprot.org/core/author | "Reed J.C."xsd:string |
| http://purl.uniprot.org/citations/15304216 | http://purl.uniprot.org/core/author | "Cui J."xsd:string |
| http://purl.uniprot.org/citations/15304216 | http://purl.uniprot.org/core/author | "Thomas M."xsd:string |
| http://purl.uniprot.org/citations/15304216 | http://purl.uniprot.org/core/author | "Tsien R.Y."xsd:string |
| http://purl.uniprot.org/citations/15304216 | http://purl.uniprot.org/core/author | "Kitada S."xsd:string |
| http://purl.uniprot.org/citations/15304216 | http://purl.uniprot.org/core/author | "Krajewska M."xsd:string |
| http://purl.uniprot.org/citations/15304216 | http://purl.uniprot.org/core/author | "Bailly-Maitre B."xsd:string |
| http://purl.uniprot.org/citations/15304216 | http://purl.uniprot.org/core/author | "Ke N."xsd:string |
| http://purl.uniprot.org/citations/15304216 | http://purl.uniprot.org/core/author | "Kress C.L."xsd:string |
| http://purl.uniprot.org/citations/15304216 | http://purl.uniprot.org/core/author | "Lipton S.A."xsd:string |
| http://purl.uniprot.org/citations/15304216 | http://purl.uniprot.org/core/author | "Monosov E."xsd:string |
| http://purl.uniprot.org/citations/15304216 | http://purl.uniprot.org/core/author | "Digicaylioglu M."xsd:string |
| http://purl.uniprot.org/citations/15304216 | http://purl.uniprot.org/core/author | "Chae H.J."xsd:string |
| http://purl.uniprot.org/citations/15304216 | http://purl.uniprot.org/core/author | "Babendure J.R."xsd:string |
| http://purl.uniprot.org/citations/15304216 | http://purl.uniprot.org/core/author | "Banares S."xsd:string |
| http://purl.uniprot.org/citations/15304216 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15304216 | http://purl.uniprot.org/core/name | "Mol Cell"xsd:string |
| http://purl.uniprot.org/citations/15304216 | http://purl.uniprot.org/core/pages | "355-366"xsd:string |
| http://purl.uniprot.org/citations/15304216 | http://purl.uniprot.org/core/title | "BI-1 regulates an apoptosis pathway linked to endoplasmic reticulum stress."xsd:string |