| http://purl.uniprot.org/citations/15304223 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15304223 | http://www.w3.org/2000/01/rdf-schema#comment | "Five MutS homologs (MSH), which form three heterodimeric protein complexes, have been identified in eukaryotes. While the human hMSH2-hMSH3 and hMSH2-hMSH6 heterodimers operate primarily in mitotic mismatch repair (MMR), the biochemical function(s) of the meiosis-specific hMSH4-hMSH5 heterodimer is unknown. Here, we demonstrate that purified hMSH4-hMSH5 binds uniquely to Holliday Junctions. Holliday Junctions stimulate the hMSH4-hMSH5 ATP hydrolysis (ATPase) activity, which is controlled by Holliday Junction-provoked ADP-->ATP exchange. ATP binding by hMSH4-hMSH5 induces the formation of a hydrolysis-independent sliding clamp that dissociates from the Holliday Junction crossover region, embracing two homologous duplex DNA arms. Fundamental differences between hMSH2-hMSH6 and hMSH4-hMSH5 Holliday Junction recognition are detailed. Our results support the attractive possibility that hMSH4-hMSH5 stabilizes and preserves a meiotic bimolecular double-strand break repair (DSBR) intermediate."xsd:string |
| http://purl.uniprot.org/citations/15304223 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2004.06.040"xsd:string |
| http://purl.uniprot.org/citations/15304223 | http://purl.uniprot.org/core/author | "Fishel R."xsd:string |
| http://purl.uniprot.org/citations/15304223 | http://purl.uniprot.org/core/author | "Acharya S."xsd:string |
| http://purl.uniprot.org/citations/15304223 | http://purl.uniprot.org/core/author | "Berardini M."xsd:string |
| http://purl.uniprot.org/citations/15304223 | http://purl.uniprot.org/core/author | "Butz C."xsd:string |
| http://purl.uniprot.org/citations/15304223 | http://purl.uniprot.org/core/author | "Snowden T."xsd:string |
| http://purl.uniprot.org/citations/15304223 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15304223 | http://purl.uniprot.org/core/name | "Mol Cell"xsd:string |
| http://purl.uniprot.org/citations/15304223 | http://purl.uniprot.org/core/pages | "437-451"xsd:string |
| http://purl.uniprot.org/citations/15304223 | http://purl.uniprot.org/core/title | "hMSH4-hMSH5 recognizes Holliday Junctions and forms a meiosis-specific sliding clamp that embraces homologous chromosomes."xsd:string |
| http://purl.uniprot.org/citations/15304223 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/15304223 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15304223 |
| http://purl.uniprot.org/citations/15304223 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15304223 |
| http://purl.uniprot.org/uniprot/#_P54132-mappedCitation-15304223 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15304223 |
| http://purl.uniprot.org/uniprot/#_P57053-mappedCitation-15304223 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15304223 |
| http://purl.uniprot.org/uniprot/#_O43196-mappedCitation-15304223 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15304223 |
| http://purl.uniprot.org/uniprot/#_P58876-mappedCitation-15304223 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15304223 |
| http://purl.uniprot.org/uniprot/#_P62805-mappedCitation-15304223 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15304223 |
| http://purl.uniprot.org/uniprot/#_P62807-mappedCitation-15304223 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15304223 |
| http://purl.uniprot.org/uniprot/#_Q13472-mappedCitation-15304223 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15304223 |
| http://purl.uniprot.org/uniprot/#_Q06609-mappedCitation-15304223 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15304223 |
| http://purl.uniprot.org/uniprot/#_P15927-mappedCitation-15304223 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15304223 |
| http://purl.uniprot.org/uniprot/#_P33778-mappedCitation-15304223 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15304223 |