| http://purl.uniprot.org/citations/15305370 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15305370 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15305370 | http://www.w3.org/2000/01/rdf-schema#comment | "To identify tumor-suppressor genes on chromosome 10 in non-small cell lung cancers, we isolated 10 types of splicing variant of the HELLS/SMARCA6 gene transcripts. HELLS/SMARCA6 is a novel member of SNF2 family, which is implicated in cellular functions like chromatin remodeling. Variant 1 was an alternatively spliced isoform containing an insertion of a 44 ntd intronic sequence between exons 3 and 4, giving rise to a premature termination of translation. Expression of variant 1 was detected exclusively in lung cancer specimens (11 of 43 cases, 26%) but was not detected in corresponding normal tissues. The D10S520 marker in the proximity of the HELLS/SMARCA6 gene showed prevalent allelic loss (41%) compared to flanking markers (25-31%). These results suggest that loss of function of HELLS/SMARCA6 by allelic loss and aberrant proteins by tumor-specific exon creation may result in epigenetic deregulation, leading lung cells to malignancy or its progression."xsd:string |
| http://purl.uniprot.org/citations/15305370 | http://purl.org/dc/terms/identifier | "doi:10.1002/ijc.20407"xsd:string |
| http://purl.uniprot.org/citations/15305370 | http://purl.org/dc/terms/identifier | "doi:10.1002/ijc.20407"xsd:string |
| http://purl.uniprot.org/citations/15305370 | http://purl.uniprot.org/core/author | "Shimizu K."xsd:string |
| http://purl.uniprot.org/citations/15305370 | http://purl.uniprot.org/core/author | "Shimizu K."xsd:string |
| http://purl.uniprot.org/citations/15305370 | http://purl.uniprot.org/core/author | "Shimizu N."xsd:string |
| http://purl.uniprot.org/citations/15305370 | http://purl.uniprot.org/core/author | "Shimizu N."xsd:string |
| http://purl.uniprot.org/citations/15305370 | http://purl.uniprot.org/core/author | "Tanaka N."xsd:string |
| http://purl.uniprot.org/citations/15305370 | http://purl.uniprot.org/core/author | "Tanaka N."xsd:string |
| http://purl.uniprot.org/citations/15305370 | http://purl.uniprot.org/core/author | "Yano M."xsd:string |
| http://purl.uniprot.org/citations/15305370 | http://purl.uniprot.org/core/author | "Yano M."xsd:string |
| http://purl.uniprot.org/citations/15305370 | http://purl.uniprot.org/core/author | "Kobayashi K."xsd:string |
| http://purl.uniprot.org/citations/15305370 | http://purl.uniprot.org/core/author | "Kobayashi K."xsd:string |
| http://purl.uniprot.org/citations/15305370 | http://purl.uniprot.org/core/author | "Ichimura K."xsd:string |
| http://purl.uniprot.org/citations/15305370 | http://purl.uniprot.org/core/author | "Ichimura K."xsd:string |
| http://purl.uniprot.org/citations/15305370 | http://purl.uniprot.org/core/author | "Shigematsu H."xsd:string |
| http://purl.uniprot.org/citations/15305370 | http://purl.uniprot.org/core/author | "Shigematsu H."xsd:string |
| http://purl.uniprot.org/citations/15305370 | http://purl.uniprot.org/core/author | "Ouchida M."xsd:string |
| http://purl.uniprot.org/citations/15305370 | http://purl.uniprot.org/core/author | "Ouchida M."xsd:string |
| http://purl.uniprot.org/citations/15305370 | http://purl.uniprot.org/core/author | "Tsukuda K."xsd:string |
| http://purl.uniprot.org/citations/15305370 | http://purl.uniprot.org/core/author | "Tsukuda K."xsd:string |
| http://purl.uniprot.org/citations/15305370 | http://purl.uniprot.org/core/author | "Inaki Y."xsd:string |
| http://purl.uniprot.org/citations/15305370 | http://purl.uniprot.org/core/author | "Inaki Y."xsd:string |