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http://purl.uniprot.org/citations/15306172http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/15306172http://www.w3.org/2000/01/rdf-schema#comment"

Background

Infection and inflammation are associated with atherosclerosis. During infection and inflammation, HDL decreases and there are changes in the levels of several HDL-associated proteins. To identify changes in the protein composition of HDL during infection and inflammation, a proteomic approach was utilized.

Methods and results

Using two-dimensional gel electrophoresis and mass spectrometry, we found the expected increases in apolipoprotein (apo) SAA and apo E, as well as a decrease in apo A-I on HDL isolated from mice injected with endotoxin. We identified apo A-IV and apo A-V as positive acute-phase proteins in mouse HDL. We also found an increase in hepatic mRNA levels of apo A-IV and apo A-V after injection of endotoxin. Interleukin-6 increased apo A-IV and apo A-V mRNA levels in Hep3B cells. Additionally, we demonstrated that the protein levels of apo A-II in acute-phase HDL and the hepatic mRNA levels of apo A-II were decreased.

Conclusions

Apo A-IV and A-V are positive acute-phase proteins that increase in the serum during inflammation while apo A-II is a negative acute-phase protein in mice. Similar to other positive and negative acute-phase proteins, changes in hepatic production account for the changes in serum levels. However, the changes in apo A-IV and apo A-V, two apolipoproteins whose activities are not fully understood, may serve functions other than regulating lipid metabolism during the acute-phase response (APR). Coupled with the other changes in HDL proteins that occur, these changes are likely to alter the functional properties of HDL perhaps increasing the risk of atherosclerosis."xsd:string
http://purl.uniprot.org/citations/15306172http://purl.org/dc/terms/identifier"doi:10.1016/j.atherosclerosis.2004.04.018"xsd:string
http://purl.uniprot.org/citations/15306172http://purl.uniprot.org/core/author"Medzihradszky K.F."xsd:string
http://purl.uniprot.org/citations/15306172http://purl.uniprot.org/core/author"Feingold K.R."xsd:string
http://purl.uniprot.org/citations/15306172http://purl.uniprot.org/core/author"Grunfeld C."xsd:string
http://purl.uniprot.org/citations/15306172http://purl.uniprot.org/core/author"Khovidhunkit W."xsd:string
http://purl.uniprot.org/citations/15306172http://purl.uniprot.org/core/author"Moser A.H."xsd:string
http://purl.uniprot.org/citations/15306172http://purl.uniprot.org/core/author"Shigenaga J.K."xsd:string
http://purl.uniprot.org/citations/15306172http://purl.uniprot.org/core/author"Kane J.P."xsd:string
http://purl.uniprot.org/citations/15306172http://purl.uniprot.org/core/author"Duchateau P.N."xsd:string
http://purl.uniprot.org/citations/15306172http://purl.uniprot.org/core/author"Naya-Vigne J."xsd:string
http://purl.uniprot.org/citations/15306172http://purl.uniprot.org/core/date"2004"xsd:gYear
http://purl.uniprot.org/citations/15306172http://purl.uniprot.org/core/name"Atherosclerosis"xsd:string
http://purl.uniprot.org/citations/15306172http://purl.uniprot.org/core/pages"37-44"xsd:string
http://purl.uniprot.org/citations/15306172http://purl.uniprot.org/core/title"Apolipoproteins A-IV and A-V are acute-phase proteins in mouse HDL."xsd:string
http://purl.uniprot.org/citations/15306172http://purl.uniprot.org/core/volume"176"xsd:string
http://purl.uniprot.org/citations/15306172http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/15306172
http://purl.uniprot.org/citations/15306172http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/15306172
http://purl.uniprot.org/uniprot/#_P06728-mappedCitation-15306172http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/15306172
http://purl.uniprot.org/uniprot/#_Q01488-mappedCitation-15306172http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/15306172
http://purl.uniprot.org/uniprot/#_Q810I7-mappedCitation-15306172http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/15306172
http://purl.uniprot.org/uniprot/#_Q9DBN0-mappedCitation-15306172http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/15306172
http://purl.uniprot.org/uniprot/#_Q8C7G5-mappedCitation-15306172http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/15306172
http://purl.uniprot.org/uniprot/Q01488http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/15306172
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