| http://purl.uniprot.org/citations/15306688 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15306688 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15306688 | http://www.w3.org/2000/01/rdf-schema#comment | "The Caenorhabditis elegans F-box protein SEL-10 and its human homolog have been proposed to regulate LIN-12 Notch signaling by targeting for ubiquitin-mediated proteasomal degradation LIN-12 Notch proteins and SEL-12 PS1 presenilins, the latter of which have been implicated in Alzheimer's disease. We found that sel-10 is the same gene as egl-41, which previously had been defined by gain-of-function mutations that semidominantly cause masculinization of the hermaphrodite soma. Our results demonstrate that mutations causing loss-of-function of sel-10 also have masculinizing activity, indicating that sel-10 functions to promote female development. Genetically, sel-10 acts upstream of the genes fem-1, fem-2, and fem-3 and downstream of her-1 and probably tra-2. When expressed in mammalian cells, SEL-10 protein coimmunoprecipitates with FEM-1, FEM-2, and FEM-3, which are required for masculinization, and FEM-1 and FEM-3 are targeted by SEL-10 for proteasomal degradation. We propose that SEL-10-mediated proteolysis of FEM-1 and FEM-3 is required for normal hermaphrodite development."xsd:string |
| http://purl.uniprot.org/citations/15306688 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0405087101"xsd:string |
| http://purl.uniprot.org/citations/15306688 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0405087101"xsd:string |
| http://purl.uniprot.org/citations/15306688 | http://purl.uniprot.org/core/author | "Jaeger S."xsd:string |
| http://purl.uniprot.org/citations/15306688 | http://purl.uniprot.org/core/author | "Jaeger S."xsd:string |
| http://purl.uniprot.org/citations/15306688 | http://purl.uniprot.org/core/author | "Horvitz H.R."xsd:string |
| http://purl.uniprot.org/citations/15306688 | http://purl.uniprot.org/core/author | "Horvitz H.R."xsd:string |
| http://purl.uniprot.org/citations/15306688 | http://purl.uniprot.org/core/author | "Conradt B."xsd:string |
| http://purl.uniprot.org/citations/15306688 | http://purl.uniprot.org/core/author | "Conradt B."xsd:string |
| http://purl.uniprot.org/citations/15306688 | http://purl.uniprot.org/core/author | "Schwartz H.T."xsd:string |
| http://purl.uniprot.org/citations/15306688 | http://purl.uniprot.org/core/author | "Schwartz H.T."xsd:string |
| http://purl.uniprot.org/citations/15306688 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15306688 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15306688 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/15306688 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/15306688 | http://purl.uniprot.org/core/pages | "12549-12554"xsd:string |
| http://purl.uniprot.org/citations/15306688 | http://purl.uniprot.org/core/pages | "12549-12554"xsd:string |
| http://purl.uniprot.org/citations/15306688 | http://purl.uniprot.org/core/title | "The Caenorhabditis elegans F-box protein SEL-10 promotes female development and may target FEM-1 and FEM-3 for degradation by the proteasome."xsd:string |
| http://purl.uniprot.org/citations/15306688 | http://purl.uniprot.org/core/title | "The Caenorhabditis elegans F-box protein SEL-10 promotes female development and may target FEM-1 and FEM-3 for degradation by the proteasome."xsd:string |
| http://purl.uniprot.org/citations/15306688 | http://purl.uniprot.org/core/volume | "101"xsd:string |
| http://purl.uniprot.org/citations/15306688 | http://purl.uniprot.org/core/volume | "101"xsd:string |
| http://purl.uniprot.org/citations/15306688 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15306688 |
| http://purl.uniprot.org/citations/15306688 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15306688 |