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| http://purl.uniprot.org/citations/15308097 | http://www.w3.org/2000/01/rdf-schema#comment | "The immune system detects viral infections and mutations in parenchymal cells when antigens from these cells are crosspresented on MHC class I molecules of professional antigen-presenting cells (APC). Exogenous antigens are crosspresented through TAP-dependent (cytosolic) or poorly understood TAP-independent (vacuolar) pathways. The TAP-independent pathway is blocked by the cysteine protease inhibitor, leupeptin, but not by proteasome inhibitors, which is opposite to the effects of these agents on the TAP-dependent pathway. Dendritic cells lacking the cysteine protease cathepsin S lack the TAP-independent pathway. Mice whose APC lack cathepsin S have reduced crosspriming to particulate and cell-associated antigens, as well as to influenza virus. Cathepsin S-deficient phagosomes generate a class I-presented peptide poorly. In contrast, cathepsin S-sufficient phagosomes and recombinant cathepsin S produce the mature epitope. Therefore, cathepsin S plays a major role in generating presented peptides for the vacuolar pathway of crosspresentation, and this mechanism is active in vivo."xsd:string |
| http://purl.uniprot.org/citations/15308097 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2004.07.004"xsd:string |
| http://purl.uniprot.org/citations/15308097 | http://purl.uniprot.org/core/author | "Shen L."xsd:string |
| http://purl.uniprot.org/citations/15308097 | http://purl.uniprot.org/core/author | "Rock K.L."xsd:string |
| http://purl.uniprot.org/citations/15308097 | http://purl.uniprot.org/core/author | "Sigal L.J."xsd:string |
| http://purl.uniprot.org/citations/15308097 | http://purl.uniprot.org/core/author | "Boes M."xsd:string |
| http://purl.uniprot.org/citations/15308097 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15308097 | http://purl.uniprot.org/core/name | "Immunity"xsd:string |
| http://purl.uniprot.org/citations/15308097 | http://purl.uniprot.org/core/pages | "155-165"xsd:string |
| http://purl.uniprot.org/citations/15308097 | http://purl.uniprot.org/core/title | "Important role of cathepsin S in generating peptides for TAP-independent MHC class I crosspresentation in vivo."xsd:string |
| http://purl.uniprot.org/citations/15308097 | http://purl.uniprot.org/core/volume | "21"xsd:string |
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