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| http://purl.uniprot.org/citations/15310273 | http://www.w3.org/2000/01/rdf-schema#comment | "Major membrane proteins have been quantitatively analyzed in erythrocytes and platelets from patients with homozygous (splenectomized and non-splenectomized) and heterozygous forms of beta-thalassemia depending on severity of clinical manifestation of this disease. Quantitative analysis of erythrocyte membrane proteins revealed increase in alpha- and beta-spectrin. (In non-splenectomized patients with homozygous beta-thalassemia the amount of this protein was lower than in corresponding controls.) Besides spectrin, the increase of 2.1-2.3 fractions of ankyrin, and the decrease of band 3 protein (anion-transport protein), 4.1, palladin, and glyceraldehyde-3-phosphate dehydrogenase were also found. Analysis of major platelet membrane proteins revealed significant increase in gelsolin. This increase was found in all forms of beta-thalassemia irrespective of gender. Significant changes in platelet membrane protein fractions were found in patients (especially non-splenectomized) with homozygous beta-thalassemia. These included significant decrease in myosin, profilin, and gamma-actin and increase in actin-binding protein in both male and female patients. The content of other protein fractions (alpha-actinin, tubulin, tropomyosin) remained unchanged. Changes in protein fractions of erythrocytes and platelets correlated with severity of clinical manifestation of the disease."xsd:string |
| http://purl.uniprot.org/citations/15310273 | http://purl.org/dc/terms/identifier | "doi:10.1023/b:biry.0000040198.62939.56"xsd:string |
| http://purl.uniprot.org/citations/15310273 | http://purl.uniprot.org/core/author | "Alekperova G.A."xsd:string |
| http://purl.uniprot.org/citations/15310273 | http://purl.uniprot.org/core/author | "Javadov S.A."xsd:string |
| http://purl.uniprot.org/citations/15310273 | http://purl.uniprot.org/core/author | "Orudzhev A.G."xsd:string |
| http://purl.uniprot.org/citations/15310273 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15310273 | http://purl.uniprot.org/core/name | "Biochemistry (Mosc)"xsd:string |
| http://purl.uniprot.org/citations/15310273 | http://purl.uniprot.org/core/pages | "748-753"xsd:string |
| http://purl.uniprot.org/citations/15310273 | http://purl.uniprot.org/core/title | "Analysis of erythrocyte and platelet membrane proteins in various forms of beta-thalassemia."xsd:string |
| http://purl.uniprot.org/citations/15310273 | http://purl.uniprot.org/core/volume | "69"xsd:string |
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