| http://purl.uniprot.org/citations/15314028 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15314028 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15314028 | http://www.w3.org/2000/01/rdf-schema#comment | "Environmental cues transduced by an endocrine network converge on Caenorhabditis elegans nuclear receptor DAF-12 to mediate arrest at dauer diapause or continuous larval development. In adults, DAF-12 selects long-lived or short-lived modes. How these organismal choices are molecularly specified is unknown. Here we show that coregulator DIN-1 and DAF-12 physically and genetically interact to instruct organismal fates. Homologous to human corepressor SHARP, DIN-1 comes in long (L) and short (S) isoforms, which are nuclear localized but have distinct functions. DIN-1L has embryonic and larval developmental roles. DIN-1S, along with DAF-12, regulates lipid metabolism, larval stage-specific programs, diapause, and longevity. Epistasis experiments reveal that din-1S acts in the dauer pathways downstream of lipophilic hormone, insulin/IGF, and TGFbeta signaling, the same point as daf-12. We propose that the DIN-1S/DAF-12 complex serves as a molecular switch that implements slow life history alternatives in response to diminished hormonal signals."xsd:string |
| http://purl.uniprot.org/citations/15314028 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.312604"xsd:string |
| http://purl.uniprot.org/citations/15314028 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.312604"xsd:string |
| http://purl.uniprot.org/citations/15314028 | http://purl.uniprot.org/core/author | "Antebi A."xsd:string |
| http://purl.uniprot.org/citations/15314028 | http://purl.uniprot.org/core/author | "Antebi A."xsd:string |
| http://purl.uniprot.org/citations/15314028 | http://purl.uniprot.org/core/author | "Ludewig A.H."xsd:string |
| http://purl.uniprot.org/citations/15314028 | http://purl.uniprot.org/core/author | "Ludewig A.H."xsd:string |
| http://purl.uniprot.org/citations/15314028 | http://purl.uniprot.org/core/author | "Hutter H."xsd:string |
| http://purl.uniprot.org/citations/15314028 | http://purl.uniprot.org/core/author | "Hutter H."xsd:string |
| http://purl.uniprot.org/citations/15314028 | http://purl.uniprot.org/core/author | "Weitzel C."xsd:string |
| http://purl.uniprot.org/citations/15314028 | http://purl.uniprot.org/core/author | "Weitzel C."xsd:string |
| http://purl.uniprot.org/citations/15314028 | http://purl.uniprot.org/core/author | "Bethke A."xsd:string |
| http://purl.uniprot.org/citations/15314028 | http://purl.uniprot.org/core/author | "Bethke A."xsd:string |
| http://purl.uniprot.org/citations/15314028 | http://purl.uniprot.org/core/author | "Gerisch B."xsd:string |
| http://purl.uniprot.org/citations/15314028 | http://purl.uniprot.org/core/author | "Gerisch B."xsd:string |
| http://purl.uniprot.org/citations/15314028 | http://purl.uniprot.org/core/author | "Kober-Eisermann C."xsd:string |
| http://purl.uniprot.org/citations/15314028 | http://purl.uniprot.org/core/author | "Kober-Eisermann C."xsd:string |
| http://purl.uniprot.org/citations/15314028 | http://purl.uniprot.org/core/author | "Neubert K."xsd:string |
| http://purl.uniprot.org/citations/15314028 | http://purl.uniprot.org/core/author | "Neubert K."xsd:string |
| http://purl.uniprot.org/citations/15314028 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15314028 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15314028 | http://purl.uniprot.org/core/name | "Genes Dev."xsd:string |
| http://purl.uniprot.org/citations/15314028 | http://purl.uniprot.org/core/name | "Genes Dev."xsd:string |