| http://purl.uniprot.org/citations/15314172 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15314172 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15314172 | http://www.w3.org/2000/01/rdf-schema#comment | "Expression of a dominant negative atypical protein kinase C (aPKC), PKCzeta, prevents nuclear translocation of extracellular regulated kinase 2 (ERK-2), p27 nuclear reduction, and DNA synthesis induced by estradiol in human mammary cancer-derived MCF-7 cells. aPKC action upstream of these events has been analyzed. In hormone-stimulated NIH 3T3 and Cos cells ectopically expressing human estrogen receptor alpha (hERalpha), aPKC is activated by phosphatidylinositol 3-kinase (PI 3-kinase) and, in turn, controls the Ras/MEK-1/ERK cascade. In MCF-7 and Cos cells stimulated by hormone, PI 3-kinase activates PKCzeta by Thr410 phosphorylation. Serine phosphorylation of PKCzeta is simultaneously induced. PKCzeta activation leads to recruitment of Ras to a multimolecular complex that also includes hERalpha, Src, PI 3-kinase, and aPKC. We propose that PKCzeta pushes Ras and the signaling complex close together in such a way that it facilitates the Src-dependent Ras activation. This activation is crucial for the interplay between estradiol-triggered signaling and cell cycle machinery."xsd:string |
| http://purl.uniprot.org/citations/15314172 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.24.17.7643-7653.2004"xsd:string |
| http://purl.uniprot.org/citations/15314172 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.24.17.7643-7653.2004"xsd:string |
| http://purl.uniprot.org/citations/15314172 | http://purl.uniprot.org/core/author | "Lombardi M."xsd:string |
| http://purl.uniprot.org/citations/15314172 | http://purl.uniprot.org/core/author | "Lombardi M."xsd:string |
| http://purl.uniprot.org/citations/15314172 | http://purl.uniprot.org/core/author | "Di Domenico M."xsd:string |
| http://purl.uniprot.org/citations/15314172 | http://purl.uniprot.org/core/author | "Di Domenico M."xsd:string |
| http://purl.uniprot.org/citations/15314172 | http://purl.uniprot.org/core/author | "Barone M.V."xsd:string |
| http://purl.uniprot.org/citations/15314172 | http://purl.uniprot.org/core/author | "Barone M.V."xsd:string |
| http://purl.uniprot.org/citations/15314172 | http://purl.uniprot.org/core/author | "Auricchio F."xsd:string |
| http://purl.uniprot.org/citations/15314172 | http://purl.uniprot.org/core/author | "Auricchio F."xsd:string |
| http://purl.uniprot.org/citations/15314172 | http://purl.uniprot.org/core/author | "Bilancio A."xsd:string |
| http://purl.uniprot.org/citations/15314172 | http://purl.uniprot.org/core/author | "Bilancio A."xsd:string |
| http://purl.uniprot.org/citations/15314172 | http://purl.uniprot.org/core/author | "Castoria G."xsd:string |
| http://purl.uniprot.org/citations/15314172 | http://purl.uniprot.org/core/author | "Castoria G."xsd:string |
| http://purl.uniprot.org/citations/15314172 | http://purl.uniprot.org/core/author | "Migliaccio A."xsd:string |
| http://purl.uniprot.org/citations/15314172 | http://purl.uniprot.org/core/author | "Migliaccio A."xsd:string |
| http://purl.uniprot.org/citations/15314172 | http://purl.uniprot.org/core/author | "Varricchio L."xsd:string |
| http://purl.uniprot.org/citations/15314172 | http://purl.uniprot.org/core/author | "Varricchio L."xsd:string |
| http://purl.uniprot.org/citations/15314172 | http://purl.uniprot.org/core/author | "de Falco A."xsd:string |
| http://purl.uniprot.org/citations/15314172 | http://purl.uniprot.org/core/author | "de Falco A."xsd:string |
| http://purl.uniprot.org/citations/15314172 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15314172 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |