| http://purl.uniprot.org/citations/15316030 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15316030 | http://www.w3.org/2000/01/rdf-schema#comment | "Although class A type I/II scavenger receptor (SR-A) is involved in numerous macrophage functions, its signaling ability remains uncertain. We used monoclonal antibodies (mAb) to specifically stimulate receptors on mouse alveolar (AMs) and peritoneal macrophages (PMs). Immobilized anti-SR-A (2F8) and anti-FcgammaR II/III (2.4G2) mAb stimulated hydrogen peroxide (H2O2) production in normal C3H/HeJ AMs (by 55% and 98%, respectively) and resident PMs (66% and 128%). The 2F8 mAb-stimulated H2O2 production resulted from specific stimulation of SR-A, since this response was absent in AMs from SR-A-deficient or C57BL/6 mice--the latter strain expressing an allelic form of SR-A, unrecognizable by 2F8 mAb. H2O2 production stimulated by anti-SR-A but not by anti-FcgammaRII/III mAb was preserved in FcgammaRI/III-deficient mice, ruling out involvement of FcgammaRs in the 2F8 mAb effect. In comparison with the FcgammaR-stimulated respiratory burst, the response to anti-SR-A mAb was delayed and, unlike the former, inhibited by pertussis toxin. Ligation of SR-A also inhibited lipopolysaccharide plus interferon-gamma-stimulated interleukin-12 (IL-12) release, by 25% in AMs and by 68% in thioglycollate-elicited PMs, consistent with different levels of SR-A expression. Neither nitrite nor IL-6 accumulation was affected by anti-SR-A mAb. SR-A-stimulated H2O2 does not seem to mediate the inhibition of IL-12 release, since the inhibition was neither reversed by scavenging of H2O2 nor mimicked by exogenous H2O2. Our results indicate that SR-A not only mediates endocytosis but can also generate signals such as H2O2, which may affect microbicidal or proinflammatory functions."xsd:string |
| http://purl.uniprot.org/citations/15316030 | http://purl.org/dc/terms/identifier | "doi:10.1189/jlb.0504270"xsd:string |
| http://purl.uniprot.org/citations/15316030 | http://purl.uniprot.org/core/author | "Kobzik L."xsd:string |
| http://purl.uniprot.org/citations/15316030 | http://purl.uniprot.org/core/author | "Jozefowski S."xsd:string |
| http://purl.uniprot.org/citations/15316030 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15316030 | http://purl.uniprot.org/core/name | "J Leukoc Biol"xsd:string |
| http://purl.uniprot.org/citations/15316030 | http://purl.uniprot.org/core/pages | "1066-1074"xsd:string |
| http://purl.uniprot.org/citations/15316030 | http://purl.uniprot.org/core/title | "Scavenger receptor A mediates H2O2 production and suppression of IL-12 release in murine macrophages."xsd:string |
| http://purl.uniprot.org/citations/15316030 | http://purl.uniprot.org/core/volume | "76"xsd:string |
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