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Objectives

Polymorphisms of transporters associated with antigen-processing (TAP) genes might influence the susceptibility to schizophrenia by altering the antigen-processing pathway. The aim of this study was to verify the relationship between schizophrenia and the polymorphisms of TAP2 genes.

Method

Two hundred and fifty-seven Korean patients diagnosed with schizophrenia according to DSM-IV and 184 normal controls participated in this study. TAP2 polymorphic residues at positions 379, 565 and 665 were typed using amplification refractory mutation system-polymerase chain reaction single-strand conformation polymorphism.

Results

Distribution of the alleles and genotypes in patients with schizophrenia was not significantly different from those of controls.

Conclusions

This study did not show the association of the TAP2 gene with schizophrenia in the Korean population."xsd:string
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http://purl.uniprot.org/citations/15318034http://purl.uniprot.org/core/author"Kim K.S."xsd:string
http://purl.uniprot.org/citations/15318034http://purl.uniprot.org/core/author"Chae J.H."xsd:string
http://purl.uniprot.org/citations/15318034http://purl.uniprot.org/core/author"Lee K.U."xsd:string
http://purl.uniprot.org/citations/15318034http://purl.uniprot.org/core/author"Bahk W.M."xsd:string
http://purl.uniprot.org/citations/15318034http://purl.uniprot.org/core/author"Jun T.Y."xsd:string
http://purl.uniprot.org/citations/15318034http://purl.uniprot.org/core/author"Pae C.U."xsd:string
http://purl.uniprot.org/citations/15318034http://purl.uniprot.org/core/author"Lew T.Y."xsd:string
http://purl.uniprot.org/citations/15318034http://purl.uniprot.org/core/date"2004"xsd:gYear
http://purl.uniprot.org/citations/15318034http://purl.uniprot.org/core/name"Psychiatr Genet"xsd:string
http://purl.uniprot.org/citations/15318034http://purl.uniprot.org/core/pages"173-176"xsd:string
http://purl.uniprot.org/citations/15318034http://purl.uniprot.org/core/title"No association of TAP2 polymorphisms in Korean patients with schizophrenia."xsd:string
http://purl.uniprot.org/citations/15318034http://purl.uniprot.org/core/volume"14"xsd:string
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