| http://purl.uniprot.org/citations/15318176 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15318176 | http://www.w3.org/2000/01/rdf-schema#comment | "Insulin receptor substrate 1 (IRS-1) is a major signaling molecule activated by the insulin and insulin-like growth factor I receptors. Recent data obtained in different cell models suggested that in addition to its conventional role as a cytoplasmic signal transducer, IRS-1 has a function in the nuclear compartment. However, the role of nuclear IRS-1 in breast cancer has never been addressed. Here we report that in estrogen receptor alpha (ERalpha)-positive MCF-7 cells, (1) a fraction of IRS-1 was translocated to the nucleus upon 17-beta-estradiol (E2) treatment; (2) E2-dependent nuclear translocation of IRS-1 was blocked with the antiestrogen ICI 182,780; (3) nuclear IRS-1 colocalized and co-precipitated with ERalpha; (4) the IRS-1:ERalpha complex was recruited to the E2-sensitive pS2 gene promoter. Notably, IRS-1 interaction with the pS2 promoter did not occur in ERalpha-negative MDA-MB-231 cells, but was observed in MDA-MB-231 cells retransfected with ERalpha. Transcription reporter assays with E2-sensitive promoters suggested that the presence of IRS-1 inhibits ERalpha activity at estrogen-responsive element-containing DNA. In summary, our data suggested that nuclear IRS-1 interacts with ERalpha and that this interaction might influence ERalpha transcriptional activity."xsd:string |
| http://purl.uniprot.org/citations/15318176 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.onc.1208014"xsd:string |
| http://purl.uniprot.org/citations/15318176 | http://purl.uniprot.org/core/author | "Tu X."xsd:string |
| http://purl.uniprot.org/citations/15318176 | http://purl.uniprot.org/core/author | "Vecchione A."xsd:string |
| http://purl.uniprot.org/citations/15318176 | http://purl.uniprot.org/core/author | "Morelli C."xsd:string |
| http://purl.uniprot.org/citations/15318176 | http://purl.uniprot.org/core/author | "Sisci D."xsd:string |
| http://purl.uniprot.org/citations/15318176 | http://purl.uniprot.org/core/author | "Cascio S."xsd:string |
| http://purl.uniprot.org/citations/15318176 | http://purl.uniprot.org/core/author | "Miller W.H. Jr."xsd:string |
| http://purl.uniprot.org/citations/15318176 | http://purl.uniprot.org/core/author | "Garofalo C."xsd:string |
| http://purl.uniprot.org/citations/15318176 | http://purl.uniprot.org/core/author | "Surmacz E."xsd:string |
| http://purl.uniprot.org/citations/15318176 | http://purl.uniprot.org/core/author | "Sauter E.R."xsd:string |
| http://purl.uniprot.org/citations/15318176 | http://purl.uniprot.org/core/author | "del Rincon S."xsd:string |
| http://purl.uniprot.org/citations/15318176 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15318176 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/15318176 | http://purl.uniprot.org/core/pages | "7517-7526"xsd:string |
| http://purl.uniprot.org/citations/15318176 | http://purl.uniprot.org/core/title | "Nuclear insulin receptor substrate 1 interacts with estrogen receptor alpha at ERE promoters."xsd:string |
| http://purl.uniprot.org/citations/15318176 | http://purl.uniprot.org/core/volume | "23"xsd:string |
| http://purl.uniprot.org/citations/15318176 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15318176 |
| http://purl.uniprot.org/citations/15318176 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15318176 |
| http://purl.uniprot.org/uniprot/#_A0A125SXW0-mappedCitation-15318176 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15318176 |
| http://purl.uniprot.org/uniprot/#_A0A125SXW1-mappedCitation-15318176 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15318176 |
| http://purl.uniprot.org/uniprot/#_Q14268-mappedCitation-15318176 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15318176 |
| http://purl.uniprot.org/uniprot/#_A0A125SXV8-mappedCitation-15318176 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15318176 |
| http://purl.uniprot.org/uniprot/#_A0A125SXV9-mappedCitation-15318176 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15318176 |