| http://purl.uniprot.org/citations/1531847 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1531847 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1531847 | http://www.w3.org/2000/01/rdf-schema#comment | "TCR V beta promoter contains a highly conserved decamer homologous to cAMP response element (CRE). Recent studies have identified this CRE decamer as the dominant transcription-activating element within the TCR V beta promoter. We have isolated cDNA clones, TCR-ATF1 and TCR-ATF2, encoding DNA-binding proteins that recognize this CRE motif. The nucleotide sequence of TCR-ATF1 has not previously been reported, whereas that of TCR-ATF2 was homologous to CRE-BP1, ATF-2, and mXBP. Both TCR-ATF1 and TCR-ATF2 shared a conserved leucine zipper and DNA binding motif with other CRE-binding proteins. TCR-ATF1 and TCR-ATF2 were expressed in all cell lines examined and in mouse embryos as early as 12.5 days. Despite binding to the same CRE motif, TCR-ATF1 and TCR-ATF2 were different from CREB in the fine nucleotide specificity. TCR-ATF bound methylated CRE and CRE mutant M4 (4C----G) that were not recognized by CREB. Additionally, TCR-ATF1 weakly recognized two other single nucleotide mutants of V beta-CRE that were not bound by TCR-ATF2 and CREB. We have further demonstrated that TCR beta-chain expression was immediately activated by cAMP. Such induction is likely mediated through V beta-CRE sequence, because the inclusion of V beta-CRE in a vector with minimum promoter (pBLCAT2) conferred the cAMP inducibility of CAT activity."xsd:string |
| http://purl.uniprot.org/citations/1531847 | http://purl.uniprot.org/core/author | "Wu M."xsd:string |
| http://purl.uniprot.org/citations/1531847 | http://purl.uniprot.org/core/author | "Wu M."xsd:string |
| http://purl.uniprot.org/citations/1531847 | http://purl.uniprot.org/core/author | "Hsueh Y.-P."xsd:string |
| http://purl.uniprot.org/citations/1531847 | http://purl.uniprot.org/core/author | "Hsueh Y.-P."xsd:string |
| http://purl.uniprot.org/citations/1531847 | http://purl.uniprot.org/core/author | "Chung C.-S."xsd:string |
| http://purl.uniprot.org/citations/1531847 | http://purl.uniprot.org/core/author | "Chung C.-S."xsd:string |
| http://purl.uniprot.org/citations/1531847 | http://purl.uniprot.org/core/author | "Lee M.-R."xsd:string |
| http://purl.uniprot.org/citations/1531847 | http://purl.uniprot.org/core/author | "Lee M.-R."xsd:string |
| http://purl.uniprot.org/citations/1531847 | http://purl.uniprot.org/core/author | "Lai M.-Z."xsd:string |
| http://purl.uniprot.org/citations/1531847 | http://purl.uniprot.org/core/author | "Lai M.-Z."xsd:string |
| http://purl.uniprot.org/citations/1531847 | http://purl.uniprot.org/core/author | "Li W.-F."xsd:string |
| http://purl.uniprot.org/citations/1531847 | http://purl.uniprot.org/core/author | "Li W.-F."xsd:string |
| http://purl.uniprot.org/citations/1531847 | http://purl.uniprot.org/core/author | "Liou M.-L."xsd:string |
| http://purl.uniprot.org/citations/1531847 | http://purl.uniprot.org/core/author | "Liou M.-L."xsd:string |
| http://purl.uniprot.org/citations/1531847 | http://purl.uniprot.org/core/date | "1992"xsd:gYear |
| http://purl.uniprot.org/citations/1531847 | http://purl.uniprot.org/core/date | "1992"xsd:gYear |
| http://purl.uniprot.org/citations/1531847 | http://purl.uniprot.org/core/name | "J. Immunol."xsd:string |
| http://purl.uniprot.org/citations/1531847 | http://purl.uniprot.org/core/name | "J. Immunol."xsd:string |
| http://purl.uniprot.org/citations/1531847 | http://purl.uniprot.org/core/pages | "1906-1912"xsd:string |
| http://purl.uniprot.org/citations/1531847 | http://purl.uniprot.org/core/pages | "1906-1912"xsd:string |
| http://purl.uniprot.org/citations/1531847 | http://purl.uniprot.org/core/title | "Isolation and characterization of nuclear proteins that bind to T cell receptor V beta decamer motif."xsd:string |
| http://purl.uniprot.org/citations/1531847 | http://purl.uniprot.org/core/title | "Isolation and characterization of nuclear proteins that bind to T cell receptor V beta decamer motif."xsd:string |