| http://purl.uniprot.org/citations/15319210 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15319210 | http://www.w3.org/2000/01/rdf-schema#comment | "Inducible nitric oxide synthase (iNOS) has been implicated in the pathophysiology of congestive heart failure (CHF). Given the extensive evidence supporting this concept, we hypothesized that iNOS deficiency (iNOS(-/-)) would attenuate the severity of CHF in mice. Mice were subjected to permanent occlusion [myocardial infarction (MI)] of the proximal left anterior descending coronary artery to produce CHF. Cardiac function was assessed in vivo using echocardiography and ultraminiature ventricular pressure catheters. Sham wild-type (n = 17), sham iNOS(-/-) (n = 8), MI wild-type (n = 56), and MI iNOS(-/-) (n = 48) mice were subjected to MI (or sham MI) and followed for 1 mo. Deficiency of iNOS did not alter survival during CHF compared with wild type (35% vs. 32%, P = not significant). Furthermore, fractional shortening and cardiac output were not significantly different between wild-type (9.6 +/-2.0% and 441 +/- 20 microl.min(-1).g(-1)) and iNOS(-/-) (9.8 +/-1.3% and 471 +/-26 microl.min(-1).g(-1)) mice. The extent of cardiac hypertrophy and pulmonary edema was also similar between wild-type and iNOS(-/-) mice. None of the indexes demonstrated any significant differences between iNOS(-/-) and wild-type mice subjected to MI. These findings indicate that deficiency of iNOS does not significantly affect severe CHF in mice after MI."xsd:string |
| http://purl.uniprot.org/citations/15319210 | http://purl.org/dc/terms/identifier | "doi:10.1152/ajpheart.00245.2004"xsd:string |
| http://purl.uniprot.org/citations/15319210 | http://purl.uniprot.org/core/author | "Yang J."xsd:string |
| http://purl.uniprot.org/citations/15319210 | http://purl.uniprot.org/core/author | "Walsh K."xsd:string |
| http://purl.uniprot.org/citations/15319210 | http://purl.uniprot.org/core/author | "Jones S.P."xsd:string |
| http://purl.uniprot.org/citations/15319210 | http://purl.uniprot.org/core/author | "Greer J.J."xsd:string |
| http://purl.uniprot.org/citations/15319210 | http://purl.uniprot.org/core/author | "Lefer D.J."xsd:string |
| http://purl.uniprot.org/citations/15319210 | http://purl.uniprot.org/core/author | "Ware P.D."xsd:string |
| http://purl.uniprot.org/citations/15319210 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15319210 | http://purl.uniprot.org/core/name | "Am J Physiol Heart Circ Physiol"xsd:string |
| http://purl.uniprot.org/citations/15319210 | http://purl.uniprot.org/core/pages | "H365-70"xsd:string |
| http://purl.uniprot.org/citations/15319210 | http://purl.uniprot.org/core/title | "Deficiency of iNOS does not attenuate severe congestive heart failure in mice."xsd:string |
| http://purl.uniprot.org/citations/15319210 | http://purl.uniprot.org/core/volume | "288"xsd:string |
| http://purl.uniprot.org/citations/15319210 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15319210 |
| http://purl.uniprot.org/citations/15319210 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15319210 |
| http://purl.uniprot.org/uniprot/#_A0A1L1STZ4-mappedCitation-15319210 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15319210 |
| http://purl.uniprot.org/uniprot/#_D3YC69-mappedCitation-15319210 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15319210 |
| http://purl.uniprot.org/uniprot/#_F8WGF2-mappedCitation-15319210 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15319210 |
| http://purl.uniprot.org/uniprot/#_P29477-mappedCitation-15319210 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15319210 |
| http://purl.uniprot.org/uniprot/#_Q8CJ25-mappedCitation-15319210 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15319210 |
| http://purl.uniprot.org/uniprot/#_Q9JJ30-mappedCitation-15319210 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15319210 |
| http://purl.uniprot.org/uniprot/#_Q9Z0J4-mappedCitation-15319210 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15319210 |
| http://purl.uniprot.org/uniprot/#_S4R255-mappedCitation-15319210 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15319210 |
| http://purl.uniprot.org/uniprot/#_S4R1D5-mappedCitation-15319210 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15319210 |