| http://purl.uniprot.org/citations/15319445 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15319445 | http://www.w3.org/2000/01/rdf-schema#comment | "The Pim-1 oncogene encodes a serine-threonine kinase that relays signals from cytokine receptors and contributes to the formation of lymphoid tumors when expressed at high levels. Here we show that the protein kinase Cdc25 C-associated kinase 1 (C-TAK1) is a binding partner and a substrate of Pim-1. A physical interaction of Pim-1 and C-TAK1 could be shown biochemically and in yeast two-hybrid assays. Immunofluorescence experiments suggested that Pim-1.C-TAK1 complexes are predominantly cytoplasmic. When transiently transfected, Pim-1 was also found in the nucleus and could recruit C-TAK1 to this compartment. Both Pim-1 and C-TAK1 underwent autophosphorylation, but only Pim-1 was able to phosphorylate C-TAK1 but not vice versa. Mass spectrometry analysis of C-TAK1 suggested that the sites of autophosphorylation and Pim-1-mediated phosphorylation are distinct and not overlapping. Phosphorylation by Pim-1 decreased C-TAK1 kinase activity significantly, in particular its ability to phosphorylate and inactivate Cdc25C, a protein that actively promotes cell cycle progression at the G(2)/M phase. Hence our findings directly suggest a novel role for Pim-1 as a positive regulator at the G(2)/M transition of the cell cycle."xsd:string |
| http://purl.uniprot.org/citations/15319445 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m404440200"xsd:string |
| http://purl.uniprot.org/citations/15319445 | http://purl.uniprot.org/core/author | "Bachmann M."xsd:string |
| http://purl.uniprot.org/citations/15319445 | http://purl.uniprot.org/core/author | "Xing P.X."xsd:string |
| http://purl.uniprot.org/citations/15319445 | http://purl.uniprot.org/core/author | "Hoffmann I."xsd:string |
| http://purl.uniprot.org/citations/15319445 | http://purl.uniprot.org/core/author | "Hennemann H."xsd:string |
| http://purl.uniprot.org/citations/15319445 | http://purl.uniprot.org/core/author | "Moroy T."xsd:string |
| http://purl.uniprot.org/citations/15319445 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15319445 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/15319445 | http://purl.uniprot.org/core/pages | "48319-48328"xsd:string |
| http://purl.uniprot.org/citations/15319445 | http://purl.uniprot.org/core/title | "The oncogenic serine/threonine kinase Pim-1 phosphorylates and inhibits the activity of Cdc25C-associated kinase 1 (C-TAK1): a novel role for Pim-1 at the G2/M cell cycle checkpoint."xsd:string |
| http://purl.uniprot.org/citations/15319445 | http://purl.uniprot.org/core/volume | "279"xsd:string |
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