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| http://purl.uniprot.org/citations/15325071 | http://www.w3.org/2000/01/rdf-schema#comment | "Prothymosin a is a small, acidic, ubiquitous protein, thought to play a role in cell proliferation, carcinogenesis and apoptosis. We have reported earlier that in the interphase nucleus prothymosin a exhibits a punctuated nuclear distribution associated with transcription sites. Moreover, the protein was found to localize in 1-6 subnuclear domains where PML and CstF64 proteins were also identified. In the present study we followed the subcellular distribution of prothymosin a during mitosis. Our data identify prothymosin a to colocalize with alpha-tubulin in the mitotic spindle throughout mitosis, and to decorate the midbody during cytokinesis. Moreover nocodazole treatment disrupted prothymosin alpha and alpha-tubulin colocalization at the centrosomes of the interphase cell. Prothymosin a was also found to decorate gamma-tubulin identified centrosomes, during mitosis. Taken together our colocalization study suggests involvement of prothymosin a, in the formation, maintenance, or functioning of the mitotic spindle."xsd:string |
| http://purl.uniprot.org/citations/15325071 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.biolcel.2004.04.002"xsd:string |
| http://purl.uniprot.org/citations/15325071 | http://purl.uniprot.org/core/author | "Vareli K."xsd:string |
| http://purl.uniprot.org/citations/15325071 | http://purl.uniprot.org/core/author | "Frangou-Lazaridis M."xsd:string |
| http://purl.uniprot.org/citations/15325071 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15325071 | http://purl.uniprot.org/core/name | "Biol Cell"xsd:string |
| http://purl.uniprot.org/citations/15325071 | http://purl.uniprot.org/core/pages | "421-428"xsd:string |
| http://purl.uniprot.org/citations/15325071 | http://purl.uniprot.org/core/title | "Prothymosin alpha is localized in mitotic spindle during mitosis."xsd:string |
| http://purl.uniprot.org/citations/15325071 | http://purl.uniprot.org/core/volume | "96"xsd:string |
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