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http://purl.uniprot.org/citations/15325281http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/15325281http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/15325281http://www.w3.org/2000/01/rdf-schema#comment"Nucleomorphin from Dictyostelium discoideum is a nuclear calmodulin-binding protein that is a member of the BRCT-domain containing cell cycle checkpoint proteins. Two differentially expressed isoforms, NumA and NumB, share an extensive acidic domain (DEED) that when deleted produces highly multinucleated cells. We performed a yeast two-hybrid screen of a Dictyostelium cDNA library using NumA as bait. Here we show that nucleomorphin interacts with calcium-binding protein 4a (CBP4a) in a Ca(2+)-dependent manner. Further deletion analysis suggests this interaction requires residues found within the DEED domain. NumA and CBP4a mRNAs are expressed at the same stages of development. CBP4a belongs to a large family of Dictyostelium CBPs, for which no cellular or developmental functions had previously been determined. Since the interaction of CBP4a with nucleomorphin requires the DEED domain, this suggests that CBP4a may respond to Ca(2+)-signalling through modulating factors that might function in concert to regulate nuclear number."xsd:string
http://purl.uniprot.org/citations/15325281http://purl.org/dc/terms/identifier"doi:10.1016/j.bbrc.2004.07.168"xsd:string
http://purl.uniprot.org/citations/15325281http://purl.org/dc/terms/identifier"doi:10.1016/j.bbrc.2004.07.168"xsd:string
http://purl.uniprot.org/citations/15325281http://purl.uniprot.org/core/author"Myre M.A."xsd:string
http://purl.uniprot.org/citations/15325281http://purl.uniprot.org/core/author"Myre M.A."xsd:string
http://purl.uniprot.org/citations/15325281http://purl.uniprot.org/core/author"O'Day D.H."xsd:string
http://purl.uniprot.org/citations/15325281http://purl.uniprot.org/core/author"O'Day D.H."xsd:string
http://purl.uniprot.org/citations/15325281http://purl.uniprot.org/core/date"2004"xsd:gYear
http://purl.uniprot.org/citations/15325281http://purl.uniprot.org/core/date"2004"xsd:gYear
http://purl.uniprot.org/citations/15325281http://purl.uniprot.org/core/name"Biochem. Biophys. Res. Commun."xsd:string
http://purl.uniprot.org/citations/15325281http://purl.uniprot.org/core/name"Biochem. Biophys. Res. Commun."xsd:string
http://purl.uniprot.org/citations/15325281http://purl.uniprot.org/core/pages"665-671"xsd:string
http://purl.uniprot.org/citations/15325281http://purl.uniprot.org/core/pages"665-671"xsd:string
http://purl.uniprot.org/citations/15325281http://purl.uniprot.org/core/title"Dictyostelium calcium-binding protein 4a interacts with nucleomorphin, a BRCT-domain protein that regulates nuclear number."xsd:string
http://purl.uniprot.org/citations/15325281http://purl.uniprot.org/core/title"Dictyostelium calcium-binding protein 4a interacts with nucleomorphin, a BRCT-domain protein that regulates nuclear number."xsd:string
http://purl.uniprot.org/citations/15325281http://purl.uniprot.org/core/volume"322"xsd:string
http://purl.uniprot.org/citations/15325281http://purl.uniprot.org/core/volume"322"xsd:string
http://purl.uniprot.org/citations/15325281http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/15325281
http://purl.uniprot.org/citations/15325281http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/15325281
http://purl.uniprot.org/citations/15325281http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/15325281
http://purl.uniprot.org/citations/15325281http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/15325281
http://purl.uniprot.org/uniprot/Q54RF4http://purl.uniprot.org/core/citationhttp://purl.uniprot.org/citations/15325281
http://purl.uniprot.org/uniprot/Q9U7C9http://purl.uniprot.org/core/citationhttp://purl.uniprot.org/citations/15325281