| http://purl.uniprot.org/citations/15326200 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15326200 | http://www.w3.org/2000/01/rdf-schema#comment | "Accurate chromosome alignment at metaphase and subsequent segregation of condensed chromosomes is a complex process involving elaborate and only partially characterized molecular machinery. Although several spindle associated molecular motors have been shown to be essential for mitotic function, only a few chromosome arm--associated motors have been described. Here, we show that human chromokinesin human HKIF4A (HKIF4A) is an essential chromosome-associated molecular motor involved in faithful chromosome segregation. HKIF4A localizes in the nucleoplasm during interphase and on condensed chromosome arms during mitosis. It accumulates in the mid-zone from late anaphase and localizes to the cytokinetic ring during cytokinesis. RNA interference--mediated depletion of HKIF4A in human cells results in defective prometaphase organization, chromosome mis-alignment at metaphase, spindle defects, and chromosome mis-segregation. HKIF4A interacts with the condensin I and II complexes and HKIF4A depletion results in chromosome hypercondensation, suggesting that HKIF4A is required for maintaining normal chromosome architecture. Our results provide functional evidence that human KIF4A is a novel component of the chromosome condensation and segregation machinery functioning in multiple steps of mitotic division."xsd:string |
| http://purl.uniprot.org/citations/15326200 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.200401142"xsd:string |
| http://purl.uniprot.org/citations/15326200 | http://purl.uniprot.org/core/author | "Mazumdar M."xsd:string |
| http://purl.uniprot.org/citations/15326200 | http://purl.uniprot.org/core/author | "Misteli T."xsd:string |
| http://purl.uniprot.org/citations/15326200 | http://purl.uniprot.org/core/author | "Sundareshan S."xsd:string |
| http://purl.uniprot.org/citations/15326200 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15326200 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/15326200 | http://purl.uniprot.org/core/pages | "613-620"xsd:string |
| http://purl.uniprot.org/citations/15326200 | http://purl.uniprot.org/core/title | "Human chromokinesin KIF4A functions in chromosome condensation and segregation."xsd:string |
| http://purl.uniprot.org/citations/15326200 | http://purl.uniprot.org/core/volume | "166"xsd:string |
| http://purl.uniprot.org/citations/15326200 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15326200 |
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| http://purl.uniprot.org/uniprot/#_Q07866-mappedCitation-15326200 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15326200 |
| http://purl.uniprot.org/uniprot/#_B3KNC0-mappedCitation-15326200 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15326200 |
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| http://purl.uniprot.org/uniprot/#_A6NNZ2-mappedCitation-15326200 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15326200 |
| http://purl.uniprot.org/uniprot/#_B7ZC32-mappedCitation-15326200 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15326200 |
| http://purl.uniprot.org/uniprot/#_O14782-mappedCitation-15326200 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15326200 |
| http://purl.uniprot.org/uniprot/#_Q12840-mappedCitation-15326200 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15326200 |
| http://purl.uniprot.org/uniprot/#_Q13509-mappedCitation-15326200 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15326200 |
| http://purl.uniprot.org/uniprot/#_Q13885-mappedCitation-15326200 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15326200 |
| http://purl.uniprot.org/uniprot/#_Q14807-mappedCitation-15326200 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15326200 |
| http://purl.uniprot.org/uniprot/#_Q02224-mappedCitation-15326200 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15326200 |