| http://purl.uniprot.org/citations/1532815 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1532815 | http://www.w3.org/2000/01/rdf-schema#comment | "The TCR consists of the Ti alpha beta heterodimer and the associated CD3 chains, CD3 gamma delta epsilon zeta 2 or zeta eta. The structural relationships between the subunits of the Ti/CD3 complex are still not fully understood. To explore the roles of the individual CD3 chains for the assembly, intracellular processing, and expression of the TCR, mutants of the T cell line Jurkat were isolated. One variant, JGN, was found to produce all the Ti/CD3 components with the exception of CD3-gamma. The results indicate that: 1) the tetrameric form (Ti alpha beta-CD3 delta epsilon) of the Ti/CD3 complex is produced in the endoplasmic reticulum in the absence of CD3-gamma; 2) CD3-zeta does not associate with the Ti alpha beta-CD3 delta epsilon complex; 3) the Ti alpha beta-CD3 delta epsilon complex is not exported from the endoplasmic reticulum to the Golgi apparatus; and 4) CD3-gamma is required for cell surface expression of the Ti/CD3 complex. Transfection of the wild-type CD3-gamma gene into JGN reconstituted expression of functional Ti/CD3 complexes, and analysis of T cell lines producing different amounts of CD3-gamma indicated that CD3-gamma and CD3-delta competed for the binding to CD3-epsilon."xsd:string |
| http://purl.uniprot.org/citations/1532815 | http://purl.uniprot.org/core/author | "Geisler C."xsd:string |
| http://purl.uniprot.org/citations/1532815 | http://purl.uniprot.org/core/date | "1992"xsd:gYear |
| http://purl.uniprot.org/citations/1532815 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/1532815 | http://purl.uniprot.org/core/pages | "2437-2445"xsd:string |
| http://purl.uniprot.org/citations/1532815 | http://purl.uniprot.org/core/title | "Failure to synthesize the CD3-gamma chain. Consequences for T cell antigen receptor assembly, processing, and expression."xsd:string |
| http://purl.uniprot.org/citations/1532815 | http://purl.uniprot.org/core/volume | "148"xsd:string |
| http://purl.uniprot.org/citations/1532815 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/1532815 |
| http://purl.uniprot.org/citations/1532815 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/1532815 |
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| http://purl.uniprot.org/uniprot/#_Q3U4Y3-mappedCitation-1532815 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/1532815 |
| http://purl.uniprot.org/uniprot/#_P11942-mappedCitation-1532815 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/1532815 |
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| http://purl.uniprot.org/uniprot/P11942 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/1532815 |
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