RDF/XMLNTriplesTurtleShow queryShare
SubjectPredicateObject
http://purl.uniprot.org/citations/15329369http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/15329369http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/15329369http://www.w3.org/2000/01/rdf-schema#comment"Three members of the SIBLING family of integrin-binding phosphoglycoproteins (bone sialoprotein, BSP; osteopontin, OPN; and dentin matrix protein-1, DMP1) were recently shown to bind with high affinity (nM) and to activate 3 different matrix metalloproteinases (MMP-2, MMP-3, and MMP-9, respectively) in vitro. The current study was designed to document the possible biological relevance of the SIBLING-MMP activation pathway in vivo by showing that these 3 SIBLINGs and their known MMP partners are co-expressed in normal adult tissue. BSP, OPN, and DMP1 were invariably co-expressed with their partner MMPs in salivary glands of humans and mice. The 2 SIBLING proteins without known MMP partners, dentin sialophosphoprotein (DSPP) and matrix extracellular phosphoglycoprotein (MEPE), were also expressed in salivary glands. Expression of all SIBLINGs in this normal, non-mineralizing epithelial tissue suggests that they serve at least one function in vivo other than directly promoting matrix mineralization--a function we hypothesize involves local activation of MMPs."xsd:string
http://purl.uniprot.org/citations/15329369http://purl.org/dc/terms/identifier"doi:10.1177/154405910408300902"xsd:string
http://purl.uniprot.org/citations/15329369http://purl.org/dc/terms/identifier"doi:10.1177/154405910408300902"xsd:string
http://purl.uniprot.org/citations/15329369http://purl.uniprot.org/core/author"Fisher L.W."xsd:string
http://purl.uniprot.org/citations/15329369http://purl.uniprot.org/core/author"Fisher L.W."xsd:string
http://purl.uniprot.org/citations/15329369http://purl.uniprot.org/core/author"Ogbureke K.U."xsd:string
http://purl.uniprot.org/citations/15329369http://purl.uniprot.org/core/author"Ogbureke K.U."xsd:string
http://purl.uniprot.org/citations/15329369http://purl.uniprot.org/core/date"2004"xsd:gYear
http://purl.uniprot.org/citations/15329369http://purl.uniprot.org/core/date"2004"xsd:gYear
http://purl.uniprot.org/citations/15329369http://purl.uniprot.org/core/name"J. Dent. Res."xsd:string
http://purl.uniprot.org/citations/15329369http://purl.uniprot.org/core/name"J. Dent. Res."xsd:string
http://purl.uniprot.org/citations/15329369http://purl.uniprot.org/core/pages"664-670"xsd:string
http://purl.uniprot.org/citations/15329369http://purl.uniprot.org/core/pages"664-670"xsd:string
http://purl.uniprot.org/citations/15329369http://purl.uniprot.org/core/title"Expression of SIBLINGs and their partner MMPs in salivary glands."xsd:string
http://purl.uniprot.org/citations/15329369http://purl.uniprot.org/core/title"Expression of SIBLINGs and their partner MMPs in salivary glands."xsd:string
http://purl.uniprot.org/citations/15329369http://purl.uniprot.org/core/volume"83"xsd:string
http://purl.uniprot.org/citations/15329369http://purl.uniprot.org/core/volume"83"xsd:string
http://purl.uniprot.org/citations/15329369http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/15329369
http://purl.uniprot.org/citations/15329369http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/15329369
http://purl.uniprot.org/citations/15329369http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/15329369
http://purl.uniprot.org/citations/15329369http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/15329369
http://purl.uniprot.org/uniprot/Q9NQ76http://purl.uniprot.org/core/citationhttp://purl.uniprot.org/citations/15329369
http://purl.uniprot.org/uniprot/Q8K4L6http://purl.uniprot.org/core/citationhttp://purl.uniprot.org/citations/15329369